RT Journal Article
T1 Multi-Omics Approach Reveals Prebiotic and Potential Antioxidant Effects of Essential Oils from the Mediterranean Diet on Cardiometabolic Disorder Using Humanized Gnotobiotic Mice.
A1 Sánchez-Quintero, María José
A1 Delgado, Josué
A1 Martín-Chaves, Laura
A1 Medina-Vera, Dina
A1 Murri, Mora
A1 Becerra-Muñoz, Víctor Manuel
A1 Estévez, Mario
A1 Crespo-Leiro, María G.
A1 Paz López, Guillermo
A1 González-Jiménez, Andrés
A1 García-Ranea, Juan Antonio
A1 Queipo-Ortuño, María Isabel
A1 Plaza-Andrades, Isaac
A1 Rodríguez Capitán, Jorge
A1 Pavón-Morón, Francisco Javier
A1 Jiménez-Navarro, Manuel Francisco
K1 Arterias coronaria - Enfermedades - Aspectos nutricionales
K1 Diabetes - Aspectos nutricionales
K1 Dieta - Mediterráneo (Región)
AB Essential oils sourced from herbs commonly used in the Mediterranean diet have demonstratedadvantageous attributes as nutraceuticals and prebiotics within a model of severe cardiometabolicdisorder. The primary objective of this study was to assess the influences exerted by essential oils derived from thyme (Thymus vulgaris) and oregano (Origanum vulgare) via a comprehensive multi-omics approach within a gnotobiotic murine model featuring colonic microbiotaacquired from patients diagnosed with coronary artery disease (CAD) and type-2 diabetes mellitus(T2DM). Our findings demonstrated prebiotic and potential antioxidant effects elicited by theseessential oils. We observed a substantial increase in the relative abundance of the Lactobacillus genusin the gut microbiota, accompanied by higher levels of short-chain fatty acids and a reduction intrimethylamine N-oxide levels and protein oxidation in the plasma. Moreover, functional enrichmentanalysis of the cardiac tissue proteome unveiled an over-representation of pathways related to mitochondrial function, oxidative stress, and cardiac contraction. These findings provide compelling evidence of the prebiotic and antioxidant actions of thyme- and oregano-derived essential oils, whichextend to cardiac function. These results encourage further investigation into the promising utility ofessential oils derived from herbs commonly used in the Mediterranean diet as potential nutraceuticalinterventions for mitigating chronic diseases linked to CAD and T2DM.
PB MDPI
YR 2023
FD 2023-08-20
LK https://hdl.handle.net/10630/30558
UL https://hdl.handle.net/10630/30558
LA eng
NO Sanchez-Quintero, M. J., Delgado, J., Chaves, L. M., Medina-Vera, D., Murri, M., Becerra‐Muñoz, V. M., Estévez, M., Crespo-Leiro, M. G., López, G. F., González-Jiménez, A., Ranea, J. A. G., Queipo-Ortuño, M. I., Plaza-Andrades, I., Rodríguez-Capitán, J., Pavón-Morón, F. J., & Jiménez‐Navarro, M. (2023). Multi-Omics Approach Reveals Prebiotic and Potential Antioxidant Effects of Essential Oils from the Mediterranean Diet on Cardiometabolic Disorder Using Humanized Gnotobiotic Mice. Antioxidants, 12(8), 1643. https://doi.org/10.3390/antiox12081643
NO : This study was supported by the following projects and programs: Research projects (PI-0170-2018, PI-0131/2020, and PI-0245-2021) funded by Consejería de Salud y Familias-Junta de Andalucía andEuropean Regional Development Funds/European Social Fund (ERDF/ESF); Research Project (UMA20-FEDERJA-074) funded by Universidad de Málaga, Consejería de Economía, Conocimiento, Empresasy Universidad-Junta de Andalucía and ERDF/ESF; Research Project PAIDI2020 (ProyExcel_01009)funded by Consejería de Transformación Económica, Industria, Conocimiento y UniversidadesJunta de Andalucía and ERDF/ESF; Projects funded by Sociedad Española de Cardiología andFundación Andaluza de Cardiología; Plataforma ISCIII de Biobancos y Biomodelos de IBIMA(PT20/00101) funded by Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación-Gobierno deEspaña; CIBERCV (CB16/11/00360) funded by Instituto de Salud Carlos III, Ministerio de Ciencia eInnovación-Gobierno de España and ERDF/ESF. M.J.S.Q. holds a Senior Postdoc Researcher contract(RH-0078-2021) funded by Consejería de Salud y Familias-Junta de Andalucía and ERDF/ESF; D.M.-V.holds a PFIS contract (FI20/00227) and F.J.P.M. holds a Miguel Servet II contract (CPII19/00022)funded by Instituto de Salud Carlos III and ERDF/ESF. This study has received support from Cátedrade Terapias Avanzadas en Patología Cardiovascular (CIF Q-2918001-E), University of Málaga.Partial funding for open access charge: Universidad de Málaga
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 3 mar 2026