RT Journal Article
T1 Therapeutic strategies to recover ependymal barrier after inflammatory damage: relevance for recovering neurogenesis during development.
A1 Páez-González, Patricia
A1 López-de-San-Sebastián, Javier
A1 Cerón-Fúnez, Raquel
A1 Jiménez-Lara, Antonio Jesús
A1 Rodríguez-Pérez, Luis Manuel
K1 Desarrollo neurológico
AB The epithelium covering the surfaces of the cerebral ventricular system is known as the ependyma, and is essential for maintaining the physical and functional integrity of the central nervous system. Additionally, the ependyma plays an essential role in neurogenesis, neuroinflammatory modulation and neurodegenerative diseases. Ependyma barrier is severely affected by perinatal hemorrhages and infections that cross the blood brain barrier. The recovery and regeneration of ependyma after damage are key to stabilizing neuroinflammatory and neurodegenerative processes that are critical during early postnatal ages. Unfortunately, there are no effective therapies to regenerate this tissue in human patients. Here, the roles of the ependymal barrier in the context of neurogenesis and homeostasis are reviewed, and future research lines for development of actual therapeutic strategies are discussed.
PB Frontiers
YR 2023
FD 2023
LK https://hdl.handle.net/10630/37727
UL https://hdl.handle.net/10630/37727
LA eng
NO Ceron-Funez R, Jimenez AJ and Rodríguez-Perez LM (2023) Therapeutic strategies to recover ependymal barrier after inflammatory damage: relevance for recovering neurogenesis during development. Front. Neurosci. 17:1204197. doi: 10.3389/fnins.2023.1204197
NO The present work was supported by grant PI19/00778 (to AJ andPP-G) from the Instituto de Salud Carlos III, Spain, cofinanced byFEDER funds from the European Union. RYC-2014-16980 to PP-Gfrom the Ministerio de Economía y Competitividad, Spain; UMA18-FEDERJA-277 from Plan Operativo FEDER Andalucía 2014–2020and Universidad de Málaga to PP-G; Contrato PostdoctoralPPITD-UMA from Universidad de Málaga to LR-P; the Waite Student
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026