RT Journal Article T1 Physical therapy in Down syndrome: systematic review and meta-analysis. A1 Ruiz González, Lorena A1 Lucena-Antón, David A1 Salazar, Alejandro A1 Martín-Valero, Rocío A1 Moral-Muñoz, José Antonio K1 Síndrome de Down - Fisioterapia AB Down syndrome is the most common chromosomal abnormality, with a worldwide incidence of around 0.1% in live births. It is related to several conditions in which the physical therapy could take action-preventing co-morbidities. This study aims to evaluate the effectiveness of physical therapy in Down syndrome, to know and compare the effectiveness of different physical therapy interventions in this population.Methods: A systematic review and a meta-analysis of randomised controlled trials were conducted. The search was performed during June 2018 in the following databases: PubMed, Web of Science, Physiotherapy Evidence Database and Scopus. The studies were selected using predefined inclusion and exclusion criteria. The Physiotherapy Evidence Database scale evaluated the quality of the methods used in the studies. Subsequently, the data were extracted, and statistical analysis was performed when possible.Results: A total of 27 articles were included, of which nine contributed information to the meta-analysis. Statistical analysis showed favourable results for the strength of upper and lower limbs [standardised mean difference (SMD) = 1.46; 95% confidence interval (CI): (0.77-2.15); and SMD = 2.04; 95% CI: (1.07-3.01)] and mediolateral oscillations of balance [SMD = -3.30; 95% CI: (-5.34 to -1.26)].Conclusions: The results show the potential benefit of certain types of physical therapy interventions, specifically in strength and balance, in people with Down syndrome. There are still many aspects to clarify and new lines of research. PB Wiley YR 2019 FD 2019 LK https://hdl.handle.net/10630/35184 UL https://hdl.handle.net/10630/35184 LA eng NO Ruiz-González, L., Lucena-Antón, D., Salazar, A., Martín-Valero, R., & Moral-Munoz, J. A. (2019). Physical therapy in Down syndrome: systematic review and meta-analysis. Journal of intellectual disability research : JIDR, 63(8), 1041–1067. https://doi.org/10.1111/jir.12606 NO Política de acceso abierto tomada de: https://openpolicyfinder.jisc.ac.uk/id/publication/7080 DS RIUMA. Repositorio Institucional de la Universidad de Málaga RD 19 ene 2026