RT Journal Article
T1 Evaluation of cytotoxic effect of siphonochilone from African ginger: an in vitro analysis.
A1 Ortigosa-Palomo, Alba
A1 Fuentes-Ríos, David
A1 Quiñonero, Francisco
A1 Melguizo, Consolación
A1 Ortiz, Raúl
A1 López-Romero, Juan Manuel
A1 Prados, José
K1 Jengibre - Uso terapeútico
K1 Células - Muerte
K1 Citotoxicidad por mediación celular
AB Plants provide a wide array of compounds that can be explored for potential antican-cer properties. Siphonochilone, a furanoterpene that represents one of the maincomponents of the African plant Siphonochilus aethiopicus, shows numerous healthbenefits. However, to date, its antiproliferative properties have not been tested. Theaim of this study was to analyze the cytotoxic effects of siphonochilone on a panel ofcancer cell lines and its underlying mechanism of action. Our results demonstratedthat siphonochilone exhibited significant cytotoxic effects on pancreatic, breast, lung,colon, and liver cancer cell lines showing a IC50 ranging from 22 to 124 μM at 72 hof treatment and highlighting its cytotoxic effect against MCF7 and PANC1 breastand pancreas cancer cell lines (22.03 and 39.03 μM, respectively). Cell death in thesetumor lines was mediated by apoptosis by the mitochondrial pathway, as evidencedby siphonochilone-induced depolarization of the mitochondrial membrane potential.In addition, siphonochilone treatment involves the generation of reactive oxygenspecies that may contribute to apoptosis induction. In this work, we described forthe first time the cytotoxic properties of siphonochilone and provided data about themolecular processes of cell death. Although future studies will be necessary, ourresults support the interest in this molecule in relation to their clinical application incancer, and especially in breast and pancreatic cancer.
PB Wiley
YR 2024
FD 2024-04-23
LK https://hdl.handle.net/10630/40531
UL https://hdl.handle.net/10630/40531
LA eng
NO Environmental Toxicology. 2024;1–14.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 25 ene 2026