RT Journal Article
T1 Effect of nail thickness on visible radiation transmittance: implications for new photodynamic therapy technologies in onychomycosis
A1 Navarrete-de-Gálvez, Enrique
A1 Aguilera-Arjona, José
A1 De-Gálvez-Aranda, María Victoria
A1 Fonda-Pascual, Pablo
A1 Herrera-Ceballos, Enrique
A1 Gago-Calderon, Alfonso
K1 Diodos emisores de luz
AB Photodynamic therapy is taking importance as a nonintrusive treatment for nail onychomycosis. Knowledge of true transmittance values across nails could lead to qualitative and quantitative improvements in light- based treatments. We have characterized the spectral transmittance of healthy and fungally infected human fingernails and toenails according to nail thickness, and we propose a surface transmittance model for the small-scale optimization of light-based treatments. Transmittance of fingernails and toenails was analyzed by means of spectroradiometric measurements under solar-simulated visible light radiation (400 nm to 750 nm). The nail thickness was measured by means of microscope measurement. Transmittance was highest at longer wavelengths and decreased gradually as the wavelengths became shorter but with a significant nail transmittance of around 20% in the blue region of the spectrum. In the case of nails affected by onychomycosis, transmittance fell to under 10% because of the thickness of the nails, with no changes in spectral characteristics of transmitted light. Nail thickness is the main variable controlling exponentially light transmission in the visible spectrum and not only red radiation is effective for nail onychomycosis PDT. Blue light, the spectral band more effective for PPIX absorption is also effectively transmitted.
PB Wiley
YR 2020
FD 2020-06-13
LK https://hdl.handle.net/10630/35884
UL https://hdl.handle.net/10630/35884
LA eng
NO de Gálvez, E.N., Aguilera, J., de Gálvez, M.V., Fonda-Pascual, P., Herrera-Ceballos, E. and Gago-Calderón, A. (2020), Effect of Nail Thickness on Visible Radiation Transmittance: Implications for New Photodynamic Therapy Technologies in Onychomycosis. Photochem Photobiol, 96: 1267-1272. https://doi.org/10.1111/php.13296
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 19 ene 2026