RT Journal Article
T1 Immune Mechanism of Epileptogenesis and Related Therapeutic Strategies
A1 Aguilar-Castillo, María José
A1 Cabezudo-García, Pablo
A1 Ciano-Petersen, Nicolas Lundahl
A1 García-Martín, Guillermina
A1 Marín-Gracia, Marta
A1 Estivill-Torrús, Guillermo
A1 Serrano-Castro, Pedro Jesús
K1 Epilepsia
AB Immunologic and neuroinflammatory pathways have been found to play a major role in the pathogenesis of many neurological disorders such as epilepsy, proposing the use of novel therapeutic strategies. In the era of personalized medicine and in the face of the exhaustion of anti-seizure therapeutic resources, it is worth looking at the current or future possibilities that neuroimmunomodulator or anti-inflammatory therapy can offer us in the management of patients with epilepsy. For this reason, we performed a narrative review on the recent advances on the basic epileptogenic mechanisms related to the activation of immunity or neuroinflammation with special attention to current and future opportunities for novel treatments in epilepsy. Neuroinflammation can be considered a universal phenomenon and occurs in structural, infectious, post-traumatic, autoimmune, or even genetically based epilepsies. The emerging research developed in recent years has allowed us to identify the main molecular pathways involved in these processes. These molecular pathways could constitute future therapeutic targets for epilepsy. Different drugs current or in development have demonstrated their capacity to inhibit or modulate molecular pathways involved in the immunologic or neuroinflammatory mechanisms described in epilepsy. Some of them should be tested in the future as possible antiepileptic drug
PB IOAP-MPDI
YR 2022
FD 2022-03-19
LK https://hdl.handle.net/10630/24251
UL https://hdl.handle.net/10630/24251
LA eng
NO Aguilar-Castillo MJ, Cabezudo-García P, Ciano-Petersen NL, García-Martin G, Marín-Gracia M, Estivill-Torrús G, Serrano-Castro PJ. Immune Mechanism of Epileptogenesis and Related Therapeutic Strategies. Biomedicines. 2022; 10(3):716. https://doi.org/10.3390/biomedicines10030716
NO This research was funded by Andalusian Network of Clinical and Translational Research in Neurology (Neuro-RECA) of the Consejería de Salud y Familias de la Junta de Andalucía (Code: RIC-0111-2019). Partial funding for open access charge: Universidad de Málaga
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 21 ene 2026