RT Journal Article T1 CardioRVAR: A New R Package and Shiny Application for the Evaluation of Closed-Loop Cardiovascular Interactions A1 Chao-Écija, Álvaro A1 López-González, Manuel Víctor A1 Dawid-Milner, Marc Stefan K1 Cardiología - Innovaciones tecnológicas AB CardioRVAR is a new R package designed for the complete evaluation of closed-loop cardiovascular interactions and baroreflex sensitivity estimated from continuous non-invasive heart rate and blood pressure recordings. In this work, we highlight the importance of this software tool in the context of human cardiovascular and autonomic neurophysiology. A summary of the main algorithms that CardioRVAR uses are reviewed, and the workflow of this package is also discussed. We present the results obtained from this tool after its application in three clinical settings. These results support the potential clinical and scientific applications of this tool. The open-source tool can be downloaded from a public GitHub repository, as well as its specific Shiny application, CardioRVARapp. The open-source nature of the tool may benefit the future continuation of this work PB MDPI YR 2023 FD 2023-11 LK https://hdl.handle.net/10630/36233 UL https://hdl.handle.net/10630/36233 LA eng NO Chao-Écija, A.; LópezGonzález, M.V.; Dawid-Milner, M.S. CardioRVAR: A New R Package and Shiny Application for the Evaluation of Closed-Loop Cardiovascular Interactions. Biology 2023, 12, 1438. https://doi.org/10.3390/ biology12111438 DS RIUMA. Repositorio Institucional de la Universidad de Málaga RD 19 ene 2026