RT Journal Article
T1 A near-infrared probe for detecting and interposing amyloid beta oligomerization in early Alzheimer's disease
A1 Quan, Li
A1 Moreno-González, Inés
A1 Xie, Zhigang
A1 Gámez, Nazaret
A1 Vegas-Gómez, Laura
A1 Song, Qinyong
A1 Gu, Jianhua
A1 Lin, Wenhai
A1 Gómez Gutiérrez, Rubén
A1 Wu, Tianfu
K1 Alzheimer, Enfermedad de
K1 Amiloide
K1 Aminoácidos
AB BackgroundThe misfolding and deposition of amyloid beta (Aβ) in human brain is the main hallmark of Alzheimer's disease (AD) pathology. One of the drivers of Alzheimer´s pathogenesis is the production of soluble oligomeric Aβ, which could potentially serve as a biomarker of AD.MethodsGiven that the diphenylalanine (FF) at the C-terminus of Aβ fragments plays a key role in inducing the AD pathology, based on the hydrophobic structure of FF, we synthesized a near-infrared BF2-dipyrrolmethane fluorescent imaging probe (NB) to detect both soluble and insoluble Aβ.ResultsWe found that NB not only binds Aβ, particularly oligomeric Aβ, but also interposes self-assembly of Aβ through π-π interaction between NB and FF.ConclusionThis work holds great promise in the early detection of AD and may also provide an innovative approach to decelerate and even halt AD onset and progression.
PB Wiley
YR 2023
FD 2023
LK https://hdl.handle.net/10630/39720
UL https://hdl.handle.net/10630/39720
LA eng
NO Quan Li, Moreno-Gonzalez I, Xie Z, et al. A near-infrared probe for detecting and interposing amyloid beta oligomerization in early Alzheimer's disease. Alzheimer's Dement. 2023; 19: 456–466. https://doi.org/10.1002/alz.12673
NO https://openpolicyfinder.jisc.ac.uk/id/publication/10547
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 21 ene 2026