RT Conference Proceedings
T1 In vivo and In vitro cartilage differentiation from embryonic epicardial progenitor cells
A1 Marín-Sedeño, Ernesto
A1 Ruiz-Villalba, Adrián
A1 Palmquist-Gomes, Paul
A1 Sánchez Tévar, Ana María
A1 Rico-Llanos, Gustavo Adolfo
A1 Pérez-Pomares, José María
A1 Guadix-Domínguez, Juan Antonio
K1 Corazón - Embriología
K1 Tejidos (Biología)
K1 Cartílagos
K1 Células cardiacas
AB The presence of cartilage tissue in embryonic and adult hearts of various vertebrate species is a well-recorded fact. However, while the embryonic neural crest has been historically considered as the main source of cardiac cartilage, recently reported results on the wide connective potential of epicardial lineage cells suggest they could also differentiate into chondrocytes. During heart embryogenesis, the epicardial epithelium forms over the originally bare myocardial surface from epicardial progenitor (proepicardial) cells to then give rise to a large population of mesenchymal Epicardial-Derived Cells (EPDCs) that will crucially contribute to the building, growth, and maturation of the ventricle and atrioventricular cardiac structures. In this work, we describe the formation of cardiac cartilage clusters from proepicardial cells, both in vivo and in vitro. Our findings report, for the first time, cartilage formation from epicardial progenitor cells in the embryonic heart, and strongly support the concept of proepicardial cells as multipotent connective progenitors. These results are relevant to our understanding of cardiac cell complexity and responses to pathologic stimuli.
YR 2022
FD 2022
LK https://hdl.handle.net/10630/24153
UL https://hdl.handle.net/10630/24153
LA spa
NO Universidad de Málaga (UMA18-FEDERJA-146). Campus de Excelencia Internacional Andalucía Tech;Ministerio de Educación (FPU18/05219);Ministerio de Ciencias (RTI2018-095410-B-I00);ISCIII-RETICs (RD16/0011/0030);Consejería de Salud y Familias, Junta de Andalucía (PIER-0084-2019)Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 12 abr 2026