RT Journal Article
T1 Effect of apolipoprotein C3 and apolipoprotein A1 polymorphisms on postprandial response to a fat overload in metabolic syndrome patients
A1 Clemente-Postigo, María Mercedes
A1 Queipo-Ortuño, María Isabel
A1 Valdivieso-Felices, Pedro
A1 Tinahones-Madueño, Francisco José
A1 Cardona-Díaz, Fernando
K1 Apolipoproteínas
K1 Síndrome metabólico
AB Objectives: Apolipoprotein C-III (APOC3) is a component of triglyceride rich lipoproteins, and SstI polymorphism has been associated with hypertriglyceridemia. Apolipoprotein A-I (APOA1) is the major component of HDL and MspI polymorphism has been associated with APOA1 and HDL-C levels. Thus, we study the influence of these polymorphisms in the postprandial response in metabolic syndrome (MS). Design and methods: 73 MS patients and 21 healthy subjects underwent a fat overload, with measurements of their fasting and postprandial lipid profile. The APOC3 SstI and the APOA1MspI polymorphisms were genotyped. Results: No significant differences were found in the lipid profile with respect to the MspI genotype. Patients with the S2S2 APOC3 genotype had significantly higher fasting and postprandial triglyceride levels and postprandial APOC3 and chylomicron-triglyceride levels compared with the other SstI APOC3 genotypes. Conclusions: Homozygosity for the minor allele of the APOC3 SstI polymorphism was associated to a worse postprandial response in MS patients.
PB Elsevier. The Canadian Society of Clinical Chemists.
YR 2010
FD 2010
LK https://hdl.handle.net/10630/34108
UL https://hdl.handle.net/10630/34108
LA eng
NO M. Clemente-Postigo, M. Queipo-Ortuño, P. Valdivielso, F.J. Tinahones, F. Cardona, Effect of apolipoprotein C3 and apolipoprotein A1 polymorphisms on postprandial response to a fat overload in metabolic syndrome patients, Clinical Biochemistry, Volume 43, Issues 16–17, 2010, Pages 1300-1304, ISSN 0009-9120, https://doi.org/10.1016/j.clinbiochem.2010.08.014.
NO The authors wish to thank all the subjects for their collaboration, and IMABIS. We also gratefully acknowledge the help of Ian Johnstone for his expertise in preparing this manuscript and José Rioja for his technical contribution (Centro de Investigaciones Médico-Sanitarias, University of Malaga, Spain). The research group belongs to the “Centros de Investigación en Red” (CIBER, CB06/03/0018) of the “Instituto de Salud Carlos III”. This work was supported in part by a grant from the Instituto de Salud Carlos III CP07/0095, PS09/00997 and PI081655, Madrid, Spain and the Servicio Andaluz de Salud (PI325/2008).
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 19 ene 2026