RT Journal Article
T1 Do changes in microglial status underlie neurogenesis impairments and depressive-like behaviours induced by psychological stress? A systematic review in animal models
A1 Nieto-Quero, Andrea
A1 Chaves-Peña, Patricia
A1 Santín-Núñez, Luis Javier
A1 Pérez-Martín, Margarita
A1 Pedraza-Benítez, María del Carmen
K1 Neurobiología del desarrollo
AB Stress may have a negative effect on mental health and is the primary environmental risk factor in the aetiologyof depression. Nevertheless, the neurobiological mechanisms underlying this mood disorder remain poorlycharacterized. The hippocampus is a target structure of the adverse effects of stress, and hippocampal neuro-genesis plays a crucial role. However, we do not know the mechanisms by which stress impacts neurogenesis.Recent studies indicate that changes in neuroinflammation, primarily via microglial cells, may play an essentialrole in this process. However, the relationship between stress, microglial changes, and alterations in neurogenesisand their involvement in the development of depression is poorly characterized. For this reason, this systematicreview aims to synthesise and evaluate current studies that have investigated the relationship between thesevariables. Taken together, the revised data, although not entirely conclusive, seem to suggest that microglialchanges induced by psychological stress regulate neurogenesis and in turn may be responsible for the devel-opment of depressive-like behaviours, but other factors that influence these stressful experiences should not bedismissed.
PB Elsevier
YR 2021
FD 2021-11
LK https://hdl.handle.net/10630/23940
UL https://hdl.handle.net/10630/23940
LA eng
NO Nieto-Quero, Andrea ; Chaves-Peña, Patricia ; Santin-Nuñez, Luis Javier. Do changes in microglial status underlie neurogenesis impairments and depressive-like behaviours induced by psychological stress? A systematic review in animal models. Neurobiology of Stress Volume 15, November 2021, 100356. https://doi.org/10.1016/j.ynstr.2021.100356
NO We would like to thank the University of Malaga/CBUA for the contribution to the payment of the open access charge. This study was supported by FEDER/Ministerio de Ciencia, Innovacion ´ y Universidades – Agencia Estatal de Investigacion ´ (PSI 2017-83408-P) to C.P. and Ministerio de Universidades (FPU16/05308 to AN-Q). PC-P has been funded by the research project PSI 2017-83408- P as technician (CI-19-082).
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 28 feb 2026