RT Journal Article T1 Time course and predictors of persistent cancer‑related fatigue in long‑term breast cancer survivors: a prospective observational study A1 Álvarez-Salvago, Francisco A1 Jiménez-García, José Daniel A1 Martínez-Amat, Antonio A1 Hita-Contreras, Fidel A1 Aibar-Almazán, Agustín K1 Cáncer - Complicaciones y secuelas K1 Enfermos de cáncer - Rehabilitación K1 Dolor K1 Salud K1 Fatiga (Fisiología) AB Purpose: The present study investigated whether the level of cancer-related fatigue (CRF) after finishingoncology treatment was related to higher levels of persistent CRF and its relationship with both functionaland psychological disturbances. Second, to identify potential predictors of persistent CRF.Methods: Eighty BC survivors were classified into non-fatigued (≤3.9) or fatigued (≥4), according totheir Piper Fatigue Scale total score after finishing oncology treatment. Time course of fatigue and theimpact on its domains, pain, mood state, perceived physical fitness, the level of physical activity andquality of life were assessed at ≥5 years.Results: Women classified as fatigued after finishing oncology treatment, had not only a higherprevalence of persistent CRF (41.2%) at the reassessment, but also greater levels of pain (P=.006 to .048)and mood disturbances (P=.007 to .015), and lower levels of physical fitness condition (P=.002 to .039)and quality of life (P<.001 to <.05) over time. Regression analyses revealed that “sadness/depression”,“global health status”, “physical activity level”, and “type of treatment” were significant predictors ofpersistent CRF (r2=.692).Conclusion: Higher levels of CRF implied greater levels of persistent CRF and a lower functional andpsychological profile over time. 69.2% of the variability of persistent CRF was explained. PB Springer YR 2022 FD 2022-12-03 LK https://hdl.handle.net/10630/41434 UL https://hdl.handle.net/10630/41434 LA spa NO Álvarez-Salvago, F., Jiménez-García, J. D., Martínez-Amat, A., Hita-Contreras, F., & Aibar-Almazán, A. (2023). Time course and predictors of persistent cancer-related fatigue in long-term breast cancer survivors: a prospective observational study. Supportive Care in Cancer, 31(351). NO https://openpolicyfinder.jisc.ac.uk/id/publication/8241?from=single_hit DS RIUMA. Repositorio Institucional de la Universidad de Málaga RD 21 ene 2026