RT Journal Article
T1 Methods for causality assessment of idiosyncratic drug-induced liver injury
A1 García-Cortés, Miren
A1 Matilla-Cabello, Gonzalo
A1 Lucena-González, María Isabel
K1 Hígado - Enfermedades
K1 Medicamentos - Toxicología
K1 Medicina
AB The diagnosis of idiosyncratic drug-induced liver injury (DILI) is a challenging taskdue to the lack of specific features or definitive diagnostic tools. A minimum of clinicaland pharmacological information is required, together with laboratory and imagingtests to exclude other causes of liver injury. Several standardized methods havebeen developed to support clinical judgement and establish causality assessment, themost widely used being the Roussel Uclaf Causality Assessment Method—RUCAM—and structured Expert Opinion. More recently, an evidence-based,revised RUCAM, Electronic Causality Assessment Method—RECAM—has been developed and, althoughstill a work in progress, may replace RUCAM scoring in the future. Internationalcollaborative networks and ongoing research efforts are key to advancing biomarkerqualification and validation and developing new in vitro patient-basedmethods that will help improve DILI diagnosis and move towards a personalized medicine approach.
PB Wiley
YR 2024
FD 2024
LK https://hdl.handle.net/10630/32434
UL https://hdl.handle.net/10630/32434
LA eng
NO García-Cortés M, Matilla-Cabello G, Lucena MI. Methods for causality assessment of idiosyncratic drug-induced liver injury. Liver Int. 2024 Aug 21. doi: 10.1111/liv.16083. Epub ahead of print. PMID: 39166347.
NO Funding for open access charge: Universidad de Málaga / CBUA. This research was supported by grants from the Instituto de Salud Carlos III, cofounded by the Fondo Europeo de Desarrollo Regional-FEDERcontract numbers: PI21/01248; PID2022-140169OB-C21, PT23/00137. Cofounded by European Union. CIBERehd and Plataforma de Investigación Clinica are funded by the Instituto de Salud Carlos III. G.M.C. holds a FPU PhD fellowship from the Spanish Ministry of Science, Innovation and Universities (FPU22/03868). The funders had no role in study design, data collection and analysis, decision to publish or prepare the manuscript.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 19 ene 2026