RT Journal Article
T1 Coumarin: a novel player in microbial quorum sensing and biofilm formation inhibition.
A1 Reen, F. Jerry
A1 Gutiérrez Barranquero, Jose A.
A1 López Parages, María
A1 O´Gara, Fergal
K1 Resistencia a los antiinfecciosos
AB Antibiotic resistance is a growing threat worldwide, causing serious problems in the treatment of microbial infections. Thediscovery and development of new drugs is urgently needed to overcome this problem which has greatly undermined the clinicaleffectiveness of conventional antibiotics. An intricate cell-cell communication system termed quorum sensing (QS) and thecoordinated multicellular behaviour of biofilm formation have both been identified as promising targets for the treatment andclinical management of microbial infections. QS systems allow bacteria to adapt rapidly to harsh conditions, and are known topromote the formation of antibiotic tolerant biofilm communities. It is well known that biofilm is a recalcitrant mode of growthand it also increases bacterial resistance to conventional antibiotics. The pharmacological properties of coumarins have been welldescribed, and these have included several that possess antimicrobial properties. More recently, reports have highlighted thepotential role of coumarins as alternative therapeutic strategies based on their ability to block the QS signalling systems and toinhibit the formation of biofilms in clinically relevant pathogens. In addition to human infections, coumarins have also beenfound to be effective in controlling plant pathogens, infections in aquaculture, food spoilage and in reducing biofouling caused byeukaryotic organisms. Thus, the coumarin class of small molecule natural product are emerging as a promising strategy to combatbacterial infections in the new era of antimicrobial resistance
PB Springer Nature
YR 2018
FD 2018-02-01
LK https://hdl.handle.net/10630/36974
UL https://hdl.handle.net/10630/36974
LA eng
NO Reen FJ, Gutiérrez-Barranquero JA, Parages ML, O Gara F. Coumarin: a novel player in microbial quorum sensing and biofilm formation inhibition. Appl Microbiol Biotechnol. 2018 Mar;102(5):2063-2073. doi: 10.1007/s00253-018-8787-x. Epub 2018 Feb 1. PMID: 29392389; PMCID: PMC5814477
NO This research was supported in part by grants awarded by the European Commission (FP7-PEOPLE-2013-ITN, 607786; FP7-KBBE-2012-6, CP-TP-312184; FP7-KBBE-2012-6, 311975; OCEAN 2011-2, 287589; Marie Curie 256596; EU-634486), Science Foundation Ireland (SSPC-2, 12/RC/2275; 13/TIDA/B2625; 12/TIDA/B2411; 12/TIDA/B2405; 14/TIDA/2438, 15/TIDA/2977), the Department of Agriculture and Food (FIRM/RSF/CoFoRD; FIRM 08/RDC/629; FIRM 1/F009/MabS; FIRM 13/F/516), the Irish Research Council for Science, Engineering and Technology (PD/2011/2414; GOIPG/2014/647), the Health Research Board/Irish Thoracic Society (MRCG-2014-6), the Marine Institute (Beaufort award C2CRA 2007/082) and Teagasc (Walsh Fellowship 2013). FJR and FOG acknowledge support from Enterprise Ireland (CF-2017-0757-P).
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 3 mar 2026