RT Journal Article
T1 LPS in combination with amoxicillin increases BAT sensitivity to amoxicillin IgE‐mediated hypersensitivity
A1 Céspedes Lagos, José Antonio
A1 Fernández-Santamaría, Rubén
A1 Bogas Herrera, Gádor
A1 Ariza Veguillas, Adriana
A1 Doña, Inmaculada
A1 Salas, María
A1 Labella, Marina
A1 Fernández-Duarte, Tahía Diana
A1 Mayorga Mayorga, Cristobalina
A1 Torres-Jaén, María Josefa
A1 Frecha, Cecilia
K1 Alergia a los medicamentos
K1 Antibióticos - Efectos secundarios
AB β-lactams (BLs), and among them, amoxicillin (AX) are the most current prescribed antibiotics to treat bacterial infections,1 and their use is related to an increasing prevalence of drug hypersensitivity reactions (DHRs),2 being mainly immediate IgE-mediated, allergic reactions.3 The basophil activation test (BAT) is a currently accepted complementary in vitro tool to detect these reactions to BLs, however its sensitivity is far from optimal, ranging from 20% to 55%, with specificities of 90%–95%.4 This limitation can be explained, in part, by the small size of drugs that make them behave as haptens, and/or the need for other elements, that were present during the sensitization and/or acute phase of the reaction, and absent in the sample at resolution phase and, therefore, in the in vitro tests. In the context of BL intake during an infection, pathogen-associated molecular patterns (PAMP) can interact with Toll-like receptors (TLR) on immune cell surfaces to potentially stimulate proinflammatory cytokine production and contribute to basophil degranulation.5 In this study, we evaluated whether TLR ligand (TLR-L) interaction together to AX increased BAT sensitivity.
PB Wiley
YR 2024
FD 2024
LK https://hdl.handle.net/10630/31233
UL https://hdl.handle.net/10630/31233
LA eng
NO Céspedes, J.A., Fernández-Santamaría, R., Bogas, G., Veguillas, A.A., Doña, I., Salas, M., Labella, M., Fernández Duarte, T.D., Mayorga, C., Torres, M.J. and Frecha, C.A. (2024), LPS in combination with amoxicillin increases BAT sensitivity to amoxicillin IgE-mediated hypersensitivity. Allergy. https://doi.org/10.1111/all.16133
NO Funding for open access charge: Universidad de Málaga / CBUA
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026