RT Journal Article
T1 An array of bengamide E analogues modified at the terminal olefinic position: Synthesis and antimor properties.
A1 Martín-Gálvez, Francisca
A1 García-Ruiz, Cristina
A1 Sánchez-Ruiz, Antonio
A1 Valeriote, Frederick A.
A1 Sarabia-García, Francisco Ramón
K1 Síntesis asimétrica
K1 Síntesis orgánica
K1 Antineoplásicos
AB Based on our previously described synthetic strategy for bengamide E, a natural product of marine origin with antitumor activity, a small library of analogues modified at the terminal olefinic position was generated with the objective of investigating the effect of structural modifications on antitumor properties. Biological evaluation of these analogues, consisting of IC50 determinations against various tumor cell lines, revealed important aspects with respect to the structural requirements of this olefinic position for activity. Interestingly, the analogue possessing a cyclopentyl group displayed greater potency than the parent bengamide E, representing a key finding upon which to base further investigations into the design of new analogues with promising biological activities.
PB Chemistry Europe · European Chemical Societies Publishing
YR 2013
FD 2013-03-19
LK https://hdl.handle.net/10630/35017
UL https://hdl.handle.net/10630/35017
LA eng
NO F. Martín-Gálvez, C. García-Ruiz, A. Sánchez-Ruiz, F. A. Valeriote, F. Sarabia An array of bengamide E analogues modified at the terminal olefinic position: synthesis and antitumor properties. ChemMedChem 2023, 8(5), 819-831. https://doi.org/10.1002/cmdc.201300033
NO https://openpolicyfinder.jisc.ac.uk/id/publication/1533
NO This work was financially supported by the Ministerio de Ciencia e Innovación (ref. CTQ2010-16933), Junta de Andalucía (FQM-03329), and fellowships from Junta de Andalucía (F.M.-G.) and Ministerio de Ciencia e Innovación (C.G.-R.). We thank Dr. J.I. Trujillo (St. Louis, MO) for assistance in the preparation of this manuscript. We thank Unidad de Espectroscopía de Masas de la Universidad de Granada for exact mass spectroscopic assistance.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 19 ene 2026