RT Conference Proceedings
T1 The immunomodulator dimethyl taconite inhibits several key steps of angiogenesis in cultured endothelial cells
A1 Vidal-Valenzuela, Isabel
A1 Fernández-Florido, Elena
A1 Marrero Capitán, Ana Dácil
A1 Castilla, Laura
A1 Rodríguez-Quesada, Ana María
A1 Martínez-Póveda, Beatriz Amparo
A1 Medina-Torres, Miguel Ángel
K1 Angiogénesis
AB Dimethyl itaconate (DMI) is a cell-permeable derivative of itaconate, a known immunomodulator metabolite synthesized from the Krebs cycle intermediate cis-aconitate by the enzyme aconitate dehydrogenase. Although DMI is not metabolized into itaconate intracellularly, immunomodulatory, anti-inflammatory and anti-oxidative effects has been described for this compound. Some of these processes affected by DMI are directly related to angiogenesis; however, nothing has been published yet in this field. The aim of this work is to evaluate the potential effect of DMI in different key steps of the angiogenic process.
YR 2022
FD 2022
LK https://hdl.handle.net/10630/25749
UL https://hdl.handle.net/10630/25749
LA eng
NO Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 19 ene 2026