RT Conference Proceedings
T1 Synthesis of new bengamide analogues and encapsulation into thermo-responsive magnetic nanoparticles
A1 Porras Alcalá, Cristina
K1 Cáncer - Tratamiento
AB The development and identification of new antitumoral drugs has become a research area of great interest and maximum priority. Firstly, to overcome the secondary effects frequently shown by current antitumorals and, secondly, to prevent the appearance of tumours resistance to these agents. Marine sponges corresponding to the Jaspidae family have proved to be a prolific source of bioactive natural products. Among these, the bengamides have showed an important biological profile, including antitumor, antibiotic and anthelmintic properties. We describe here a study directed towards the total synthesis of bengamides including their encapsulation into temperature-sensitive microgels having magnetic Fe3O4 cores. Magnetic nanoparticles were prepared by the coprecipitation method and show an acrylic acid surface functionalization. We chose poly(N-isopropylacrylamide) (PNIPAM) as polymeric material, which was grown by a free radical polymerization process.
YR 2019
FD 2019-09-16
LK https://hdl.handle.net/10630/18349
UL https://hdl.handle.net/10630/18349
LA eng
NO Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 19 ene 2026