RT Journal Article
T1 Development of the ventricular myocardial trabeculae in Scyliorhinus canicula (Chondrichthyes): evolutionary implications
A1 López-Unzu, Miguel A.
A1 Durán-Boyero, Ana Carmen
A1 Rodríguez, Cristina
A1 Soto-Navarrete, María Teresa
A1 Sans-Coma, Valentín
A1 Fernández-Corujo, Borja
K1 Válvulas cardíacas
AB The development of the ventricular myocardial trabeculae occurs in three steps: emergence,trabeculation and remodeling. The whole process has been described in vertebrates with two differentmyocardial structural types, spongy (zebrafish) and compact (chicken and mouse). In this context, twoalternative mechanisms of myocardial trabeculae emergence have been identified: (1) in chicken andmouse, the endocardial cells invade the two-layered myocardium; (2) in zebrafish, cardiomyocytesfrom the monolayered myocardium invaginate towards the endocardium. Currently, the process hasnot been studied in detail in vertebrates having a mixed type of ventricular myocardium, with aninner trabecular and an outer compact layer, which is presumptively the most primitive morphologyin gnathostomes. We studied the formation of the mixed ventricular myocardium in the lesser spotteddogfish (Scyliorhinus canicula, Elasmobranchii), using light, scanning and transmission electronmicroscopy. Our results show that early formation of the mixed ventricular myocardium, specificallythe emergence and the trabeculation steps, is driven by an endocardial invasion of the myocardium.The mechanism of trabeculation of the mixed ventricular myocardium in chondrichthyans is the onethat best reproduces how this developmental process has been established from the beginning ofthe gnathostome radiation. The process has been apparently preserved throughout the entire groupof sarcopterygians, including birds and mammals. In contrast, teleosts, at least those possessing amostly spongy ventricular myocardium, seem to have introduced notable changes in their myocardialtrabeculae development.
PB Springer
YR 2020
FD 2020
LK https://hdl.handle.net/10630/30113
UL https://hdl.handle.net/10630/30113
LA eng
NO López-Unzu MA, Durán AC, Rodríguez C, Soto-Navarrete MT, Sans-Coma V, Fernández B. Development of the ventricular myocardial trabeculae in Scyliorhinus canicula (Chondrichthyes): evolutionary implications. Scientific Reports (2020) 10: 14434.
NO Grant CGL2017-85090-P (Ministerio de Ciencia e Innovación, Madrid, Spain) and FEDER funds. Fellowships FPU15/03209 andPRE2018-083176 (Ministerio de Ciencia e Innovación, Madrid, Spain)
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 2 mar 2026