RT Journal Article
T1 Serum 25-Hydroxyvitamin D and Adipose Tissue Vitamin D Receptor Gene Expression: Relationship with Obesity and Type 2 Diabetes
A1 Clemente-Postigo, María Mercedes
A1 Muñoz Garach, Araceli
A1 Serrano, Marta
A1 Garrido-Sánchez, Lourdes
A1 Bernal-López, María Rosa
A1 Fernandez-García, Diego
A1 Moreno Santos, Inmaculada
A1 Garriga, Nuria
A1 Castellano-Castillo, Daniel
A1 Camargo, Antonio
A1 Fernández Real, José M
A1 Cardona-Díaz, Fernando
A1 Tinahones-Madueño, Francisco José
A1 Macías-González, Manuel
K1 Obesidad
K1 Diabetes
AB Context: The relationship between 25-hydroxyvitamin D [25(OH)D] and obesity and type 2 diabetes is not completely understood. Vitamin D receptor (VDR) expression in adipose tissue (AT) is related to obesity and might be regulated by 1,25-dihydroxyvitamin D3 [1,25(OH)2D3].Objective: To analyze serum 25(OH)D and VDR gene expression in AT according to body mass index (BMI) and glycemic status and the effect of 1,25(OH)2D3 on AT according to BMI.Design and patients: Two cohorts were studied: 1) 118 subjects classified according to their BMI (lean, overweight, obese, or morbidly obese [MO]) and their glycemic status (normoglycemic [NG] and prediabetic and diabetic [P&D]); and 2) 30 obese subjects (BMI > 30 kg/m(2)) classified as NG and P&D. VDR gene expression was analyzed during preadipocyte differentiation and in vitro stimulation with 1,25(OH)2D3 of AT explants from donors with different BMI values.Setting: University Hospital.Main outcome measures: Serum 25(OH)D, parathyroid hormone (PTH), and AT VDR gene expression.Results: 25(OH)D levels were lower in P&D than NG subjects, significantly so in the lean and MO groups (P < .05). 25(OH)D levels correlated negatively with homeostasis model of assessment for insulin resistance (HOMA-IR) (r = -0.200; P = .032) and glucose (r = -0.295; P = .001), but not with BMI. VDR gene expression was higher in MO than in the other BMI groups (P < .05). 1,25(OH)2D3 increased VDR gene expression in AT from obese patients (P < .05) but not from lean subjects. Conclusions: 25(OH)D levels are diminished in P&D compared to NG subjects, independently of BMI, and are closely related to glucose metabolism variables, suggesting that vitamin D deficiency is associated more with carbohydrate metabolism than with obesity. Moreover, AT has a different response to 1,25(OH)2D3 depending on the degree of obesity.
PB Endocrine Society
YR 2015
FD 2015
LK https://hdl.handle.net/10630/34067
UL https://hdl.handle.net/10630/34067
LA eng
NO Clemente-Postigo M, Muñoz-Garach A, Serrano M, Garrido-Sánchez L, Bernal-López MR, Fernández-García D, Moreno-Santos I, Garriga N, Castellano-Castillo D, Camargo A, Fernández-Real JM, Cardona F, Tinahones FJ, Macías-González M. Serum 25-hydroxyvitamin D and adipose tissue vitamin D receptor gene expression: relationship with obesity and type 2 diabetes. J Clin Endocrinol Metab. 2015 Apr;100(4):E591-5. doi: 10.1210/jc.2014-3016. Epub 2015 Feb 23. PMID: 25706239.
NO This study was supported by Centros de Investigación Biomédica En Red (CB06/03/0018) of the Instituto de Salud Carlos III (ISCIII) and Grants PI11/01661, PI08/1655, and PI12/02355 from the ISCIII, Madrid, Spain. M.C.-P. was the recipient of FPU (Formación de Profesorado Universitario) Grant AP2009-4537 from the Education Ministry, Madrid, Spain. L.G.-S. was supported by “Miguel Servet Type I” (CP13/00188), and F.C. by “Miguel Servet Type II” program (CP13/00023) from the ISCIII, Madrid, Spain. M.M.-G. was the recipient of the Nicolas Monarde program from the Servicio Andaluz de Salud, Junta de Andalucia, Spain (C-0029-2014).
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 21 ene 2026