RT Journal Article
T1 Exploratory, anxiety and spatial memory impairments are dissociated in mice lacking the LPA1 receptor
A1 Castilla-Ortega, María Estela
A1 Sánchez-López, Jorge
A1 Hoyo-Becerra, Carolina
A1 Matas-Rico, Elisa
A1 Zambrana-Infantes, Emma
A1 Chun, Jerold
A1 Rodriguez-de-Fonseca, Fernando
A1 Pedraza-Benítez, María del Carmen
A1 Estivill-Torrús, Guillermo
A1 Santín-Núñez, Luis Javier
K1 Hipocampo (Cerebro)
K1 Cerebro - Investigación
AB Lysophosphatidic acid (LPA) is a new, intercellular signalling molecule in the brain that has an importantrole in adult hippocampal plasticity. Mice lacking the LPA1 receptor exhibit motor, emotional and cognitive alterations. However, the potential relationship among these concomitant impairments was unclear.Wild-type and maLPA1-null mice were tested on the hole-board for habituation and spatial learning.MaLPA1-null mice exhibited reduced exploration in a novel context and a defective intersession habituation that also revealed increased anxiety-like behaviour throughout the hole-board testing. In regard tospatial memory, maLPA1 nulls failed to reach the controls’ performance at the end of the reference memory task. Moreover, their defective working memory on the first training day suggested a delayed acquisition of the task’s working memory rule, which is also a long term memory component. The temporalinterval between trials and the task’s difficulty may explain some of the deficits found in these mice. Principal components analysis revealed that alterations found in each behavioural dimension were independent. Therefore, exploratory and emotional impairments did not account for the cognitive deficits thatmay be attributed to maLPA1 nulls’ hippocampal malfunction
PB Elsevier
YR 2010
FD 2010-07
LK https://hdl.handle.net/10630/34553
UL https://hdl.handle.net/10630/34553
LA eng
NO Estela Castilla-Ortega, Jorge Sánchez-López, Carolina Hoyo-Becerra, Elisa Matas-Rico, Emma Zambrana-Infantes, Jerold Chun, Fernando Rodríguez De Fonseca, Carmen Pedraza, Guillermo Estivill-Torrús, Luis J. Santin, Exploratory, anxiety and spatial memory impairments are dissociated in mice lacking the LPA1 receptor, Neurobiology of Learning and Memory, Volume 94, Issue 1, 2010, Pages 73-82, ISSN 1074-7427, https://doi.org/10.1016/j.nlm.2010.04.003
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026