RT Journal Article
T1 High Prevalence of Sequences Included in Transmission Clusters Within Newly Diagnosed HIV-1 Patients in Southern Spain (2004-2015)
A1 González-Doménech, Carmen María
A1 Sena Corrales, Gabriel
A1 Viciana-Ramos, María Isabel
A1 Palacios-Muñoz, María Rosario
A1 Mora-Navas, Laura
A1 Clavijo-Frutos, Encarnación
A1 Santos-González, Jesús Leandro
K1 Epidemiología molecular
AB The presence of transmission clusters (TCs) and their epidemiological characteristics in a treatment-naive cohort of HIV-1 patients in southern Spain over a decade (2004-2015) were evaluated. Protease and reverse transcriptase sequences provided by each genotype test were used in the phylogenetic study, performed first by the neighbor-joining method and then confirmed by Bayesian analysis. We collected clinical, immunovirological, and demographic data for all patients included. Our cohort comprised 757 patients, 428 (56.5%) belonging to a TC. Overall, we found 123 TCs, 21 of them comprising five or more individuals and three with ≥10 sequences. Forty-three TCs (35.0%) remained active. The clustered patients were mainly men (92.8%) who had sex with men (MSM) (81.5%), Spanish (80.6%), and young adults (median age at diagnosis of 32.6 years). They had lower percentages of late diagnosis and AIDS cases (42.1% and 13.6%, respectively), whereas the presence of recent seroconverters (31.1%), HIV-1 B subtypes (79.4%), and transmission drug resistance (20.3%) increased within TCs, with regard to not-clustered individuals. Among the TCs of non-B variants, circulating recombinant forms (CRF) were predominant (87.5%), with the highest frequencies for CRF19_cpx (17.0% of non-B subtype sequences in TCs); CRF02_AG (15.9%); and CRF01_AE (9.1%). In conclusion, over half of our cohort was included within a TC. More than a third of TCs found could be considered active transmission events. Belonging to a TC was related to MSM, Spanish origin, recent seroconversion, high prevalence of resistance mutations, and B HIV subtype. Among the non-B genetic forms in TCs, we found a high prevalence of CRF19_cpx, CRF02_AG, and CRF01_AE variants.
PB Mary Ann Liebert
YR 2020
FD 2020-09-09
LK https://hdl.handle.net/10630/28963
UL https://hdl.handle.net/10630/28963
LA eng
NO González-Domenech CM, Sena-Corrales G, Viciana-Ramos I, Palacios-Muñoz R, Mora-Navas L, Clavijo-Frutos E, Santos-González J. High Prevalence of Sequences Included in Transmission Clusters Within Newly Diagnosed HIV-1 Patients in Southern Spain (2004-2015). Microb Drug Resist. 2020 Sep;26(9):1090-1097. doi: 10.1089/mdr.2019.0344.
NO This work was mainly supported by the National R+D+I Plan (RD16/0025/0032 project); the Institute of Health Carlos III (ISCIII); and the European Regional Development Fund.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026