RT Journal Article
T1 Gene3D: a domain-based resource for comparative genomics, functional annotation and protein network analysis
A1 Lees, Jonathan
A1 Yeats, Corin
A1 Perkins, James Richard
A1 Sillitoe, Ian
A1 Rentzsch, Robert
A1 Dessailly, Benoit H
A1 Orengo, Christine A.
K1 Proteínas-Bases de datos
K1 Proteínas-Clasificación
AB Gene3D http://gene3d.biochem.ucl.ac.uk is a comprehensive database of protein domain assignments for sequences from the major sequence databases. Domains are directly mapped from structures in the CATH database or predicted using a library of representative profile HMMs derived from CATH superfamilies. As previously described, Gene3D integrates many other protein family and function databases. These facilitate complex associations of molecular function, structure and evolution. Gene3D now includes a domain functional family (FunFam) level below the homologous superfamily level assignments. Additions have also been made to the interaction data. More significantly, to help with the visualization and interpretation of multi-genome scale data sets, we have developed a new, revamped website. Searching has been simplified with more sophisticated filtering of results, along with new tools based on Cytoscape Web, for visualizing protein-protein interaction networks, differences in domain composition between genomes and the taxonomic distribution of individual superfamilies.
PB Oxford University Press
YR 2012
FD 2012-01
LK https://hdl.handle.net/10630/34475
UL https://hdl.handle.net/10630/34475
LA eng
NO Jonathan Lees, Corin Yeats, James Perkins, Ian Sillitoe, Robert Rentzsch, Benoit H. Dessailly, Christine Orengo, Gene3D: a domain-based resource for comparative genomics, functional annotation and protein network analysis, Nucleic Acids Research, Volume 40, Issue D1, 1 January 2012, Pages D465–D471, https://doi.org/10.1093/nar/gkr1181
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 12 abr 2026