RT Journal Article
T1 Natural History of Idiosyncratic Drug-Induced Liver Injury and Prognostic Models
A1 Devarbhavi, Harshad
A1 Andrade-Bellido, Raúl Jesús
K1 Hígado - Enfermedades
K1 Pronóstico médico
AB Background and Aims: Drug-induced liver injury (DILI) remains a leading cause of acute liver failure worldwide. Drugs such as isoniazid, alone or in combination with other anti-tuberculosis drugs, as well as a growing number of herbal and complementary medicines, have been implicated in most cases of acute liver failure in registry studies. Methods: This review summarizes current knowdledge on the acute and chronic outcomes in patients with idiosyncratic DILI and discusses several ofthe existing prognostic models. Results and Conclusions: The reasons why some individuals progress from DILI to end-stage liver disease are still largely unknown. However, collaborative efforts over the past few decades have provided figures on the relative incidence of drug-induced acute liver failure and allowed the development of prognostic models to predict this worse outcome at the onset of the event. The outcome of chronic DILI is less well characterised due to the lack of sufficient follow-up in cohort studies, but several phenotypes of DILI can progress to chronicity, and specific drugs such as nitrofurantoin or amiodarone are classic examples of agents leading to chronic forms of DILI. Therapy for drug-induced acute liver failure and chronic DILI is mainly supportive, although some randomised clinical trials have shown beneficial effects of N-acetylcysteine and corticosteroids.
PB Wiley
YR 2025
FD 2025-05-14
LK https://hdl.handle.net/10630/38740
UL https://hdl.handle.net/10630/38740
LA eng
NO Devarbhavi, H.C. and Andrade, R.J. (2025), Natural History of Idiosyncratic Drug-Induced Liver Injury and Prognostic Models. Liver Int, 45: e70138. https://doi.org/10.1111/liv.70138
NO This study was supported by grants from Instituto de Salud Carlos III cofounded by Fondo Europeo de Desarrollo Regional-FEDER. (contract numbers: PI21/01248 and PI24/01205). Funding for open access charge: Universidad de Málaga / CBUA
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 25 ene 2026