RT Journal Article
T1 Plasma lipidome and risk of atrial fibrillation: results from the PREDIMED trial
A1 Toledo, Estefanía
A1 Wittenbecher, Clemens
A1 Razquin, Cristina
A1 Ruiz-Canela, Miguel
A1 Clish, Clary B
A1 Liang, Liming
A1 Alonso, Álvaro
A1 Hernández-Alonso, Pablo
A1 Becerra-Tomás, Nerea
A1 Arós-Borau, Fernando
A1 Corella, Dolores
A1 Ros, Emilio
A1 Estruch, Ramón
A1 García-Rodríguez, Antonio
A1 Fitó, Montserrat
A1 Lapetra, José
A1 Fiol, Miquel
A1 Alonso-Gómez, Ángel M.
A1 Serra-Majem, Lluís
A1 Deik, Amy
A1 Salas-Salvadó, Jordi
A1 Hu, Frank B.
A1 Martínez González, Miguel Ángel
K1 Alimentación - Mediterráneo (Región)
AB The potential role of the lipidome in atrial fibrillation (AF) development is still widely unknown. We aimed to assess the associationbetween lipidome profiles of the Prevención con Dieta Mediterránea (PREDIMED) trial participants and incidenceof AF. We conducted a nested case–control study (512 incident centrally adjudicated AF cases and 735 controls matchedby age, sex, and center). Baseline plasma lipids were profiled using a Nexera X2 U-HPLC system coupled to an ExactivePlus orbitrap mass spectrometer. We estimated the association between 216 individual lipids and AF using multivariableconditional logistic regression and adjusted the p values for multiple testing. We also examined the joint association oflipid clusters with AF incidence. Hitherto, we estimated the lipidomics network, used machine learning to select importantnetwork-clusters and AF-predictive lipid patterns, and summarized the joint association of these lipid patterns weightedscores. Finally, we addressed the possible interaction by the randomized dietary intervention.Forty-one individual lipids were associated with AF at the nominal level (p < 0.05), but no longer after adjustment formultiple-testing. However, the network-based score identified with a robust data-driven lipid network showed a multivariableadjustedORper+1SD of 1.32 (95% confidence interval: 1.16–1.51; p < 0.001). The score included PC plasmalogens and PEplasmalogens, palmitoyl-EA, cholesterol, CE 16:0, PC 36:4;O, and TG 53:3. No interaction with the dietary intervention wasfound. A multilipid score, primarily made up of plasmalogens, was associated with an increased risk of AF. Future studiesare needed to get further insights into the lipidome role on AF.Current Controlled Trials number, ISRCTN35739639.
PB Springer Nature
YR 2023
FD 2023-04-01
LK https://hdl.handle.net/10630/36562
UL https://hdl.handle.net/10630/36562
LA eng
NO Toledo, E., Wittenbecher, C., Razquin, C. et al. Plasma lipidome and risk of atrial fibrillation: results from the PREDIMED trial. J Physiol Biochem 79, 355–364 (2023). https://doi.org/10.1007/s13105-023-00958-0
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 19 ene 2026