RT Conference Proceedings
T1 New augmentation strategy in depression: Galanin (1-15) enhances the behavioral effects of Fluoxetine in the olfactory bulbectomy rat.
A1 Flores-Burgess, Antonio
A1 Pineda-Gómez, Juan Pedro
A1 Millón-Peñuela, Carmelo
A1 Gago-Calderón, Belén
A1 García-Durán, Laura
A1 Cantero-García, Noelia
A1 Puigcerver-Martínez, Araceli
A1 Narváez-Bueno, José Ángel
A1 Fuxe, Kjell
A1 Santín-Núñez, Luis Javier
A1 Díaz-Cabiale, Zaida
K1 Neuropsicofarmacología - Congresos
K1 Experimentación animal - Congresos
K1 Medicamentos - Ensayos - Congresos
K1 Medicamentos - Efectividad - Congresos
K1 Depresión mental - Congresos
AB Major depression is the largest contributor to global disability by years lived with disability. Selective serotonergic reuptake inhibitors, including fluoxetine (FLX), are the most commonly used antidepressant for the treatment of major depression. However, they are effective for remission in only 30% of patients. Recently, we observed that the N-terminal fragment of Galanin [GAL(1-15)] enhanced the antidepressant effects of FLX in naïve animals.In this work, we have analyzed in an animal model of depression, the olfactory bulbectomy (OBX) rats, the effect of GAL(1-15) on FLX-mediated responses in the forced swimming test (FST) and the sucrose preference test (SPT), tests related with despair and anhedonic behaviours. We have also studied the corticosterone levels in OBX rats after the coadministration of GAL(1-15)+FLX.Groups of rats received a subchronic pattern of FLX(10mg/Kg) alone or in combination with GAL(1-15)(1nmol)15min before the tests. Blood samples for corticosterone assay were collected 1h after the treatments. One-way ANOVA followed by Fisher ́s least significant difference test was used.Our results show that GAL(1-15) decreases the immobility time by 50% (p<0.05) and increases the swimming time by 30% (p<0.01) compared with FLX in the FST, and in the SPT reversed the effects of the OBX procedure increasing the sucrose intake (p<0.05) and preference (p<0.05). The coadministration of GAL(1-15)(1nmol)+FLX(10mg/kg) also reduced the OBX-increased corticosterone levels by approximately 50% (p<0.05).In conclusion, these novelty results suggest using GAL(1-15) in combination with FLX as a novel strategy fortreating depression.
YR 2022
FD 2022-07-12
LK https://hdl.handle.net/10630/24780
UL https://hdl.handle.net/10630/24780
LA eng
NO Supported by Spanish Ministry of Economy PID2020-114392RB-I00, PDC2021-121566-I00; Junta de AndaluciaP20_00026, PI-0083-2019 and UMA18-FEDERJA-008.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 21 ene 2026