RT Journal Article
T1 Gut-brain nexus: Mapping multimodal links to neurodegeneration at biobank scale
A1 Shafieinouri, Mohammad
A1 Hong, Samantha
A1 Lee, Paul Suhwan
A1 Grant, Spencer M.
A1 Khani, Marzieh
A1 Dadu, Anant
A1 Schumacher Schuh, Artur F.
A1 Makarious, Mary B.
A1 Sandon, Rodrigo
A1 Simmonds, Emily
A1 Iwaki, Hirotaka
A1 Hill, Gracelyn
A1 Blauwendraat, Cornelis
A1 Escott-Price, Valentina
A1 Qi, Yue A.
A1 Noyce, Alastair J.
A1 Reyes-Palomares, Armando
A1 Leonard, Hampton L
A1 Tansey, Malu
A1 Faghri, Faraz
A1 Singleton, Andrew B.
A1 Nalls, Mike A.
A1 Levine, Kristin S.
A1 Bandres-Ciga, Sara
K1 Alzheimer, Enfermedad de
K1 Parkinson, Enfermedad de
AB Alzheimer’s disease (AD) and Parkinson’s disease (PD) are influenced by genetic and environmental factors. We conducted a biobank-scale study to (i) identify endocrine, nutritional, metabolic, and digestive disorders with potential causal or temporal associations with AD/PD risk before diagnosis; (ii) assess plasma biomarkers’ specificity for AD/PD in the context of co-occurring gut related traits and disorders; and (iii) integrate multimodal datasets to enhance AD/PD prediction. Our findings show that several disorders were associated with increased AD/PD risk before diagnosis, with variation in the strength and timing of associations across conditions. Polygenic risk scores reveal lower genetic predisposition for AD/PD in individuals with co-occurring disorders. Moreover, the proteomic profile of AD/PD cases was influenced by comorbid gut-brain axis disorders. Last, our multimodal prediction models outperform single-modality paradigms in disease classification. This endeavor illuminates the interplay between factors involved in the gut-brain axis and the development of AD/PD, opening avenues for therapeutic targeting and early diagnosis.
PB American Academy of Arts and Sciences (AAAS)
SN 2375-2548
YR 2025
FD 2025-08
LK https://hdl.handle.net/10630/44705
UL https://hdl.handle.net/10630/44705
LA eng
NO Mohammad Shafieinouri et al. ,Gut-brain nexus: Mapping multimodal links to neurodegeneration at biobank scale.Sci. Adv.11,eadu2937(2025).DOI:10.1126/sciadv.adu2937
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 3 mar 2026