RT Journal Article
T1 A5 region modulation of the cardiorespiratory responses evoked from parabrachial cell bodies in the anaesthetised rat
A1 Dawid-Milner, Marc Stefan
A1 Lara-Muñoz, José Pablo
A1 López de Miguel, M Pilar
A1 López-González, Manuel Víctor
A1 Spyer, KM
A1 González-Barón, Salvador
K1 Respiración - Regulación - Modelos animales
K1 Corazón - Regulación - Modelos animales
K1 Experimentación animal
AB We have examined the importance of the A5 region modulating cardiorespiratory responses evoked from the parabrachial complex(PB) in spontaneously breathing rats. Cardiorespiratory changes were analyzed in response to electrical stimulation and glutamatemicroinjections into the PB (10–20 nl, 1–2 nmol) before and after ipsilateral microinjection of muscimol (50 nl, 0.25 nmol) or lidocaine(50 nl, 0.5 nmol) within the A5 region. Stimulation of medial parabrachial and Ko¨lliker–Fuse nuclei (mPB-KF) evoked a decrease inrespiratory rate (P,0.001) with a rise in blood pressure (P,0.001) and heart rate (P,0.05). After muscimol or lidocaine microinjectionswithin the A5 region, the pressor and heart rate responses to mPB-KF stimulation were reduced (P,0.05, both cases). Muscimol withinthe A5 region altered the respiratory response to glutamate stimulation of mPB-KF, evoking an increase in respiratory rate (P,0.05).Lidocaine abolished the respiratory response to mPB-KF stimulation. Stimulation of the lateral parabrachial nuclei (lPB) caused anincrease in respiratory rate (P,0.001) with a rise in blood pressure (P,0.001) and heart rate (P,0.05). Muscimol or lidocainemicroinjections within A5 region decreased heart rate (P,0.05) and pressor responses (P,0.05) evoked from lPB. The increase ofrespiratory rate persisted unchanged. To confirm functional interactions between A5 and PB, extracellular recordings of putative A5neurones were obtained during PB stimulation. Eighty-three A5 cells were recorded, 35 were activated from the mPB-KF (42%). The results indicate that neurones of the A5 region participate in the cardiorespiratory response evoked from the different regions of the PBcomplex. The possible mechanisms involved in these interactions are discussed
PB Elsevier
YR 2003
FD 2003
LK https://hdl.handle.net/10630/29463
UL https://hdl.handle.net/10630/29463
LA eng
NO Dawid Milner MS, Lara JP, López de Miguel MP, López-González MV, Spyer KM, González-Barón S. A5 region modulation of the cardiorespiratory responses evoked from parabrachial cell bodies in the anaesthetised rat. Brain Res. 2003 Aug 22;982(1):108-18. doi: 10.1016/s0006-8993(03)03005-1
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 28 feb 2026