RT Conference Proceedings
T1 Glycomimetic Ligands for C-type Lectin Recognition.
A1 Luna León, Rubén
A1 Reina Martín, José Juan
K1 Lectinas
K1 Ligandos
K1 Química orgánica
AB C-type lectin receptors (CLRs) represent pivotal sensory mechanisms orchestrating the primary immune response via dendritic cells.1 The exploration of non-native ligands as molecular tools for the manipulation of CLRs has emerged as a highly interesting research area. In the case of DC-SIGN, one of the most extensively investigated CLRs, glycomimetics have been formulated as principal compounds with a demonstrated capacity to proficiently engage DC-SIGN (Figure 1 and 2). The principal problem encountered refers to the structural complexity and challenging synthetic processes associated with these glycomimetics.In this context, we introduce a novel class of glycomimetic ligands designed for DC-SIGN that exhibit a simpler structural composition and can be readily synthesized. These ligands hold significant promise for potential applications in the field of immune regulation therapeutic (Figure 3).
YR 2023
FD 2023
LK https://hdl.handle.net/10630/28119
UL https://hdl.handle.net/10630/28119
LA eng
NO Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026