RT Journal Article
T1 Protective effects of melatonin against oxidative stress in Fmr1 knockout mice: a therapeutic research model for the fragile X syndrome
A1 Romero-Zerbo, Silvana Yanina
A1 Decara, Juan
A1 El Bekay Rizky, Rajaa
A1 Sánchez-Salido, Lourdes
A1 Del Arco-Herrera, Ignacio
A1 Rodriguez-de-Fonseca, Fernando
A1 De-Diego-Otero, María Yolanda
K1 Melatonina
K1 Sistema nervioso central
K1 Estrés oxidativo
AB Fragile X syndrome is the most common form of inherited mentalretardation. It is typically caused by a mutation of the Fragile X mental-retardation 1 (Fmr1) gene. To better understand the role of the Fmr1 geneand its gene product, the fragile X mental-retardation protein in centralnervous system functions, an fmr1 knockout mouse that is deficient in thefragile X mental-retardation protein was bred. In the present study, fragile Xmental retardation 1-knockout and wild-type mice are used to determinebehaviour and oxidative stress alterations, including reduced glutathione,oxidized glutathione and thiobarbituric acid-reactive substances, before andafter chronic treatment with melatonin or tianeptine. Reduced glutathionelevels were reduced in the brain of fmr1-knockout mice and chronicmelatonin treatment normalized the glutathione levels compared withthe control group. Lipid peroxidation was elevated in brain and testes offmr1-knockout mice and chronic melatonin treatment prevents lipidperoxidation in both tissues. Interestingly, chronic treatment with melatoninalleviated the altered parameters in the fmr1-knockout mice, includingabnormal context-dependent exploratory and anxiety behaviours andlearning abnormalities. Chronic treatment with tianeptine (a serotoninreuptake enhancer) did not normalize the behaviour in fmr1-knockout mice.The prevention of oxidative stress in the fragile X mouse model, by anantioxidant compound such as melatonin, emerges as a new and promisingapproach for further investigation on treatment trials for the disease
PB Blackwell Munksgaard
YR 2009
FD 2009
LK https://hdl.handle.net/10630/32374
UL https://hdl.handle.net/10630/32374
LA eng
NO Romero-Zerbo, Y., Decara, J., El Bekay, R., Sanchez-Salido, L., Del Arco-Herrera, I., De Fonseca, F.R. and De Diego-Otero, Y. (2009), Protective effects of melatonin against oxidative stress in Fmr1 knockout mice: a therapeutic research model for the fragile X syndrome. Journal of Pineal Research, 46: 224-234. https://doi.org/10.1111/j.1600-079X.2008.00653.x
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026