RT Journal Article
T1 The impact of cocaine on adult hippocampal neurogenesis: Potential neurobiological mechanisms and contributions to maladaptive cognition in cocaine addiction disorder
A1 Castilla-Ortega, María Estela
A1 Ladrón de Guevara-Miranda, David
A1 Serrano, Antonia
A1 Pavón, Francisco Javier
A1 Suárez, Juan
A1 Rodriguez-de-Fonseca, Fernando
A1 Santín-Núñez, Luis Javier
K1 Cocaína
AB After discovering that addictive drugs alter adult neurogenesis, the potential role of adult-born hippocampal neurons in drug addiction has become a promising research field, in which cocaine is the most frequently investigated drug. Although a substantial amount of pre-clinical evidence has accumulated, additional studies are required to reveal the mechanisms by which cocaine modulates adult hippocampal neurogenesis (AHN) and determine whether these adult-born neurons have a role in cocaine-related behaviors, such as cocaine-mediated cognitive symptoms. First, this review will summarize the cocaine-induced alterations in a number of neurobiological factors (neurotransmitters, neurotrophins, glucocorticoids, inflammatory mediators) that likely regulate both hippocampal-dependent learning and adult hippocampal neurogenesis after cocaine exposure. A separate section will provide a detailed review of the available literature that challenges the common view that cocaine reduces adult hippocampal neurogenesis. In fact, cocaine has a short-term anti-proliferative role, but the young adult-born neurons are apparently spared, or even enhanced, following certain cocaine protocols. Thus, we will try to reconcile this evidence with the hippocampal-dependent cognitive symptoms that are typically observed in cocaine addicts, and we will propose new directions for future studies to test the relevant hypothesis. Based on the evidence presented here, the regulation of adult hippocampal neurogenesis might be one of the many mechanisms by which cocaine sculpts hippocampus-dependent learning.
PB Elsevier
YR 2017
FD 2017-10-01
LK https://hdl.handle.net/10630/34087
UL https://hdl.handle.net/10630/34087
LA eng
NO Castilla-Ortega, E., Ladrón de Guevara-Miranda, D., Serrano, A., Pavón, F. J., Suárez, J., Rodríguez de Fonseca, F., & Santín, L. J. (2017). The impact of cocaine on adult hippocampal neurogenesis: Potential neurobiological mechanisms and contributions to maladaptive cognition in cocaine addiction disorder. Biochemical pharmacology, 141, 100–117. https://doi.org/10.1016/j.bcp.2017.05.003
NO Ministerio de Economía y Competitividad (Agencia Estatal de Investigación) & Fondo Europeo de Desarrollo Regional (AEI/FEDER, UE) (PSI2015-73156-JIN, PSI2013-44901-P); Red de Trastornos Adictivos (RD16/0017/0001); Ministerio de Educación, Cultura y Deporte (FPU13/04819); Sistema Nacional de Salud-Instituto de Salud Carlos III (CP14/00173, CP12/03109 y CP14/00212).
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026