RT Journal Article
T1 Central sensitisation in chronic pain conditions: latest discoveries and their potential for precision medicine
A1 Nijs, Jo
A1 George, Steven Z
A1 Clauw, Daniel J
A1 Fernández-de-Las-Peñas, César
A1 Kosek, Eva
A1 Ickmans, Kelly
A1 Fernández-Carnero, Josué
A1 Polli, Andrea
A1 Kapreli, Eleni
A1 Huysmans, Eva
A1 Cuesta-Vargas, Antonio
A1 Mani, Ramakrishnan
A1 Lundberg, Mari
A1 Leysen, Laurence
A1 Rice, David
A1 Sterling, Michele
A1 Curatolo, Michele
K1 Dolor
AB Chronic pain is a leading cause of disability globally and associated with enormous health-care costs. The discrepancy between the extent of tissue damage and the magnitude of pain, disability, and associated symptoms represents a diagnostic challenge for rheumatology specialists. Central sensitisation, defined as an amplification of neural signalling within the CNS that elicits pain hypersensitivity, has been investigated as a reason for this discrepancy. Features of central sensitisation have been documented in various pain conditions common in rheumatology practice, including fibromyalgia, osteoarthritis, rheumatoid arthritis, Ehlers-Danlos syndrome, upper extremity tendinopathies, headache, and spinal pain. Within individual pain conditions, there is substantial variation among patients in terms of presence and magnitude of central sensitisation, stressing the importance of individual assessment. Central sensitisation predicts poor treatment outcomes in multiple patient populations. The available evidence supports various pharmacological and non-pharmacological strategies to reduce central sensitisation and to improve patient outcomes in several conditions commonly seen in rheumatology practice. These data open up new treatment perspectives, with the possibility for precision pain medicine treatment according to pain phenotyping as a logical next step. With this view, studies suggest the possibility of matching non-pharmacological approaches, or medications, or both to the central sensitisation pain phenotypes.
PB Elsevier
YR 2021
FD 2021-05
LK https://hdl.handle.net/10630/36160
UL https://hdl.handle.net/10630/36160
LA eng
NO Nijs J, George SZ, Clauw DJ, Fernández-de-Las-Peñas C, Kosek E, Ickmans K, Fernández-Carnero J, Polli A, Kapreli E, Huysmans E, Cuesta-Vargas AI, Mani R, Lundberg M, Leysen L, Rice D, Sterling M, Curatolo M. Central sensitisation in chronic pain conditions: latest discoveries and their potential for precision medicine. Lancet Rheumatol. 2021 May;3(5):e383-e392. doi: 10.1016/S2665-9913(21)00032-1. Epub 2021 Mar 30. PMID: 38279393.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026