RT Conference Proceedings
T1 Effect of a spatial memory training on the persistence of cocaine-contextual memory
A1 Ávila-Gámiz, Fabiola
A1 Mañas-Padilla, María del Carmen
A1 Ladrón de Guevara-Miranda, David
A1 Gil Rodríguez, Sara
A1 Rodriguez-de-Fonseca, Fernando
A1 Castilla-Ortega, María Estela
A1 Santín-Núñez, Luis Javier
K1 Cocaína
K1 Adicción
K1 Ratones
K1 Extinción (Biología)
K1 Psicobiología -- Congresos
AB Modulation of hippocampal memories related with cocaine addiction such as cocaine-context associations could haveimportant clinical implications. It has been shown that learning-related experiences are potent modulators ofhippocampal plasticity enhancing neurogenesis. We aimed to evaluate whether a spatial learning task dependent on thehippocampus could reduce the long-term maintenance and reinstatement of these memories. Twenty male C57BL/6Jmice were first trained in a cocaine induced conditioned place preference paradigm (CPP). Then, half of them (n=10)were trained in a spatial learning task using the Morris water maze, while the other half stayed in their home-cages.Twenty seven days after conditioning, mice were tested for CPP retention and extinction. Finally, a cocaine priminginduced reinstatement of drug seeking was performed. The results showed that animals trained in the spatial task exhibited a lower long-term CPP retention memory. In addition, it was observed an attenuation of cocaine-induced reinstatement of CPP by spatial training. Further studies could elucidate the biological mechanisms underlying these effects.
YR 2019
FD 2019-07-03
LK https://hdl.handle.net/10630/17932
UL https://hdl.handle.net/10630/17932
LA eng
NO Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026