RT Conference Proceedings
T1 Galanin N-Terminal fragment (1-15) induces a stronger effect than Galanin in depression- and anxiety- like related behavioural tests in rats.
A1 Millón-Peñuela, Carmelo
A1 Narváez-Peláez, Manuel
A1 Flores-Burgess, Antonio
A1 Parrado-Romero, Concepción
A1 Puigcerver-Martínez, Araceli
A1 Coveñas, Rafael
A1 Santín-Núñez, Luis Javier
A1 Borroto Escuela, Dasiel Óscar
A1 Fuxe, Kjell
A1 Narváez-Bueno, José Ángel
A1 Díaz-Cabiale, Zaida
K1 Depresión mental
K1 Neurorreceptores
AB Galanin (GAL) and GAL Receptors are implicated in anxiety- and depression- related behaviours. The GAL N-terminal fragment (1-15) [GAL(1-15)] also induces depressant- and anxiogenic- like actions. In this work, we have compared the effects of GAL and GAL(1-15) in depression- and anxiety- related behaviours using the Forced Swimming Test (FST) and the Open Field Test (OFT).In the first set of experiments, rats (n=8-10) were injected with GAL 3nmol, GAL(1-15) 3nmol or vehicle 15min before the FST. Two sessions were conducted: a 15min. pre-test followed 24h later by 5min. test. The duration of immobility and climbing were recorded during the test. In the second set, rats (n=6-10) were injected with GAL 3nmol, GAL(1-15) 3nmol or vehicle 15min before the OFT. Time and entries in the central square during 300 Sec. were scored.In the FST, the increase in the immobility induced by GAL(1-15) was significantly higher (p<0.01) than the one induced by GAL. In the climbing response GAL(1-15) also induced a significantly stronger decrease (p<0.05) in climbing compared with GAL.In the OFT, GAL(1-15) significantly decrease the number of entries (p<0.01) and time (p<0.05) in centre while GAL lacks of effect.These results indicate that GAL(1-15) has more powerful effects than GAL in depression-like behaviour in the FST and anxiogenic-like effects in the OFT. These findings may give the basis for the development of novel therapeutic drugs targeting GAL(1-15) system for treatment of depression and anxiety disorders.
YR 2014
FD 2014-07-16
LK http://hdl.handle.net/10630/7853
UL http://hdl.handle.net/10630/7853
LA eng
NO Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026