RT Journal Article
T1 Stereoselective total synthesis of (-)-Depudecin
A1 García-Ruiz, Cristina
A1 Cheng-Sánchez, Iván
A1 Sarabia-García, Francisco Ramón
K1 Polímeros
AB The total synthesis of the natural product depudecin, an antiangiogenic microbial polyketide with inhibitory activity against histone deacetylases, is reported. Characterized by a highly oxidized 11-carbon chain containing two epoxides conjugated through a trans-disubstituted olefin, its total synthesis was efficiently accomplished by a novel asymmetric methodology of epoxide formation based on a new class of chiral sulfonium salts, allowing for the construction of the oxirane rings in an efficient and stereoselective fashion.
PB ACS
YR 2015
FD 2015
LK https://hdl.handle.net/10630/34596
UL https://hdl.handle.net/10630/34596
LA eng
NO García-Ruiz, C.; Cheng-Sánchez, I.; Sarabia, F. Stereoselective total synthesis of (-)-depudecin. Org. Lett. 2015, 17, 22, 5558-5561 ttps://doi.org/10.1021/acs.orglett.5b02697
NO This work was financially supported by the Ministerio de Economı́a y Competitividad (MINECO) (CTQ2014-60223-R). C.G.-R. thanks the Ministerio de Educación y Ciencia and Research Plan of the University of Málaga (UMA-RP) for predoctoral and postdoctoral fellowships, respectively. I.C.-S. thanks the University of Málaga (Plan Propio-Programa de Iniciación a la Investigación 2014) and Ministerio de Educación, Cultura y Deporte (Programa FPU) for predoctoral fellowships, respectively. We thank Dr. J. I. Trujillo from Pfizer (Groton, CT) for assistance in the preparation of this manuscript. we thank the Unidad de Espectroscopı́a de Masas and the NMR facility of the University of Málaga for exact mass and NMR spectroscopic assistance. This work has been awarded a “XVII Young Researchers - Esteve Award” funded by SEQT.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 19 ene 2026