RT Conference Proceedings T1 Prevention of VER in sole using PTS and PTSO-supplemented diets. A1 Gémez-Mata, Juan A1 Leiva-Rebollo, Rocío A1 García-Rosado, Esther A1 Labella Vera, Alejandro Manuel A1 Castro-López, María Dolores K1 Peces - Enfermedades por virus K1 Lenguados - Alimentación K1 Inmunología AB Viral encephalopathy and retinopathy (VER), caused by nervous necrosis virus (NNV), is one of the main viral diseasesaffecting Senegalese sole (Solea senegalensis) in Southern Europe aquaculture. This virus (genus Betanodavirus, familyNodaviridae) is classified into four species: SJNNV, RGNNV, TPNNV and BFNNV (Sahul Hameed et al., 2019). In addition,highly virulent reassortants (RGNNV/SJNNV) have been identified in VER outbreaks in sole (Olveira et al., 2009). Recently,NNV reassortant strain SsNNV19 was isolated from farmed Senegalese sole during an NNV outbreak in Southwestern Spain.Various prophylactic methods are being developed to reduce NNV infections in sole, including vaccines, supplementedfunctional feeds, and a combination of both treatments, among others. The Allium spp extracts propyl propane thiosulfinate(PTS) and propyl propane thiosulfonate (PTSO) are key compounds for the control of pathogenic microorganisms in livestock(Liu et al., 2013), and their potential use in the aquaculture industry have been tested (Cabello-Gómez et al., 2022). In thisstudy, different sole feed supplemented with PTS or PTSO were developed, and its VER protective capacity was evaluated bymeasuring post-infection mortality and the study of host oxidative stress and inflammatory response after the feeding regime. YR 2025 FD 2025-09-22 LK https://hdl.handle.net/10630/40051 UL https://hdl.handle.net/10630/40051 LA eng NO Gémez-Mata et al., 2025 NO Gémez‑Mata, J., Leiva‑Rebollo, R., García‑Rosado, E., Labella Vera, A. M., & Castro‑López, M. D. (2025, 22 de septiembre). Prevention of VER in sole using PTS and PTSO‑supplemented diets [Congreso]. Repositorio institucional Universidad de Málaga. https://hdl.handle.net/10630/40051 NO PCM_00059 DS RIUMA. Repositorio Institucional de la Universidad de Málaga RD 20 ene 2026