RT Book, Section
T1 Extracellular Matrix-Remodeling Enzymes as Targets for Natural Antiangiogenic Compounds
A1 Carrillo, Paloma
A1 García-Caballero, Melissa
A1 Bernal, Manuel
A1 Manrique-Poyato, María Inmaculada
A1 Martínez-Póveda, Beatriz Amparo
A1 Rodríguez-Quesada, Ana María
A1 Medina-Torres, Miguel Ángel
A2 Karamanos, Nikos
K1 Neovascularización
AB Angiogenesis, or new blood vessels formation, comprises a series oftight regulated and coordinated steps guided by the balance between proangiogenicand antiangiogenic signals. Although physiological angiogenesis occurs in somecontext such as embryogenesis or wound healing, it is a very restricted process inadults, therefore, it is associated to several pathologies as cancer, arthritis or age-related macular degeneration. For this purpose, plenty of compounds from naturalsources have been studied and their antiangiogenic potential has been demonstrated.Most of them are isolated from plants, such as the major catechin found in green teaepigallocatechin-3-gallate (EGCG) or the isoflavonoid genistein. Nevertheless,compounds with antiangiogenic potential can be found in several species ofanimals, fungi, algae or bacteria, for instance, aeroplysinin-1, AD0157, carrageenanderivates and rapamycin, respectively. The extracellular matrix (ECM) remodelingplays a key role in the formation of new blood vessels. The degradation of the ECMcomponents not only provides a structural scaffold for the nascent vessels, but it isalso strongly involved in endothelial cell signaling, promoting or inhibiting thiscomplex process. In this regard, targeting the ECM components entails aninteresting therapeutic strategy for the treatment of angiogenesis-related diseases.This book chapter is an updated overview of natural compounds with anantiangiogenic effect with the capability to target one or more EMC components.
PB Springer Nature Switzerland
YR 2022
FD 2022-12
LK https://hdl.handle.net/10630/37389
UL https://hdl.handle.net/10630/37389
LA eng
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 19 ene 2026