RT Journal Article
T1 Antiangiogenic potential of an olive oil extract: insights from a proteomic study
A1 Marrero Capitán, Ana Dácil
A1 Cárdenas García, Casimiro
A1 Castilla, Laura
A1 Ortega Vidal, Juan
A1 Rodríguez-Quesada, Ana María
A1 Martínez-Póveda, Beatriz Amparo
A1 Medina-Torres, Miguel Ángel
K1 Antiangiogénicos
K1 Aceite de oliva
AB Extra virgin olive oil (EVOO), a staple of the Mediterranean diet, is rich in phenolic compounds recognized for their potent bioactive effects, including anticancer and anti-inflammatory properties. However, its effects on vascular health remain relatively unexplored. In this study, we examined the impact of a “picual” EVOO extract from Jaén, Spain, on endothelial cells. Proteomic analysis revealed the modulation of angiogenesis-related processes. In subsequent in vitro experiments, the EVOO extract inhibited endothelial cell migration, adhesion, invasion, ECM degradation, and tube formation while inducing apoptosis. These results provide robust evidence of the extract’s antiangiogenic potential. Our findings highlight the potential of EVOO extracts in mitigating angiogenesis-related pathologies, such as cancer, macular degeneration, and diabetic retinopathy.
PB ACS
YR 2024
FD 2024
LK https://hdl.handle.net/10630/31609
UL https://hdl.handle.net/10630/31609
LA eng
NO Marrero, A. D., Cárdenas, C., Castilla, L., Ortega-Vidal, J., Quesada, A. R., Martínez-Poveda, B., & Medina, M. Á. (2024). Antiangiogenic Potential of an Olive Oil Extract: Insights from a Proteomic Study. Journal of Agricultural and Food Chemistry, 2024, 72, 23, 13023–13038.
NO Funding for open access charge: Universidad de Málaga / CBUA
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 19 ene 2026