RT Conference Proceedings
T1 Managing with (fluorescent)-biomimetic dendrimers
A1 Pérez-de-Inestrosa-Villatoro, Ezequiel
A1 Vida-Pol, Yolanda
A1 Collado-Martín, Daniel
A1 Nájera-Albendín, Francisco
A1 Mesa-Antunez, Pablo
A1 Ruiz-Sanchez, Antonio Jesus
A1 Molina, Noemi
A1 Morgado, Anjara
K1 Dendrímeros
K1 Compuestos organofluorados
AB Dendrimers that are modified through their peripheral groups have been employed formany biomedical purposes. Diagnosis via specific interactions with target proteins is oneof the objectives that has been given more attention. In this way, we have beendeveloping different methodologies for the detection of immunoglobulins, as an in vitromethod for the diagnosis of allergic reactions to drugs [1], [2].Specific cell interactions of surfaces grafted dendrimers have been applied to the studyof cell adhesion. We have studied also the application of dendrimer-based unevennanopatterns to evaluate the local RGD surface density effects on cell adhesion, asbioactive substrates to evaluate the impact of the RGD local surface density on thechondrogenic induction of adult human mesenchymal stem cells [3], [4], [5].Although the use of PAMAM dendrimer has allowed us to develop useful methods forthis purpose, for certain objectives we have required the development of newdendrimeric models. We have developed a new approach for the production of allaliphaticpolyamide dendrimers (BAPAD) by iterative 3,3′-diaminopivalic acidconnections as building blocks for dendrimer construction. These dendrimers werestudied in explicit solvent by atomistic forcefield-based molecular dynamics tocharacterize structural properties such as shape, radius and monomer distribution [6].Fluorescent labeling of these biomimetic dendrimers has been used as a tool to studytheir interaction with cells.
YR 2017
FD 2017-06-30
LK http://hdl.handle.net/10630/14083
UL http://hdl.handle.net/10630/14083
LA eng
NO Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026