RT Journal Article
T1 Molecular Mechanisms of Resistance to Ionizing Radiation in S. cerevisiae and Its Relationship with Aging, Oxidative Stress, and Antioxidant Activity.
A1 González Vidal, Alejandro
A1 Mercado-Sáenz, Silvia
A1 Burgos-Molina, Antonio Manuel
A1 Alamilla Presuel, Juan Carlos
A1 Alcaraz, Miguel
A1 Sendra-Portero, Francisco
A1 Ruiz-Gómez, Miguel José
K1 Saccharomyces cerevisiae - Efectos del estrés
K1 Saccharomyces cerevisiae - Efectos de la radiación
K1 Celulas - Metabolismo
K1 Estrés oxidativo
K1 Levaduras
AB The repair of the damage produced to the genome and proteome by the action of ionizingradiation, oxidizing agents, and during aging is important to maintain cellular homeostasis. Many ofthe metabolic pathways influence multiple processes. In this way, this work aims to study the relationshipbetween resistance/response to ionizing radiation, cellular aging, and the response mechanismsto oxidative stress, free radicals, reactive oxygen species (ROS), and antioxidant activity in the yeastS. cerevisiae. Systems biology allows us to use tools that reveal the molecular mechanisms common todifferent cellular response phenomena. The results found indicate that homologous recombination,non-homologous end joining, and base excision repair pathways are the most important commonprocesses necessary to maintain cellular homeostasis. The metabolic routes of longevity regulationare those that jointly contribute to the three phenomena studied. This study proposes eleven commonbiomarkers for response/resistance to ionizing radiation and aging (EXO1, MEC1, MRE11, RAD27,RAD50, RAD51, RAD52, RAD55, RAD9, SGS1, YKU70) and two biomarkers for response/resistanceto radiation and oxidative stress, free radicals, ROS, and antioxidant activity (NTG1, OGG1). Inaddition, it is important to highlight that the HSP104 protein could be a good biomarker common tothe three phenomena studied.
PB MDPI
YR 2023
FD 2023-08-30
LK https://hdl.handle.net/10630/27435
UL https://hdl.handle.net/10630/27435
LA eng
NO González-Vidal, A.; Mercado-Sáenz, S.; Burgos-Molina, A.M.; Alamilla-Presuel, J.C.; Alcaraz, M.; Sendra-Portero, F.; Ruiz-Gómez, M.J. Molecular Mechanisms of Resistance to Ionizing Radiation in S. cerevisiae and Its Relationship with Aging, Oxidative Stress, and Antioxidant Activity. Antioxidants 2023, 12, 1690. https://doi.org/ 10.3390/antiox12091690
NO Partial funding for open access charge: Universidad de Málaga/CBUA
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 3 mar 2026