RT Journal Article
T1 The noni anthraquinone damnacanthal is a multi-kinase inhibitor with potent anti-angiogenic effects
A1 García-Vilas, Javier A.
A1 Pino-Ángeles, Almudena
A1 Martínez-Póveda, Beatriz Amparo
A1 Rodríguez-Quesada, Ana María
A1 Medina-Torres, Miguel Ángel
K1 Cancer
AB The natural bioactive compound damnacanthal inhibits several tyrosine kinases. Herein, weshow that -in fact- damancanthal is a multi kinase inhibitor. A docking and molecular dynamicssimulation approach allows getting further insight on the inhibitory effect of damnacanthal onthree different kinases: vascular endothelial growth factor receptor-2, c-Met and focal adhesionkinase. Several of the kinases targeted and inhibited by damnacanthal are involved inangiogenesis. Ex vivo and in vivo experiments clearly demonstrate that, indeed, damnacanthalis a very potent inhibitor of angiogenesis. A number of in vitro assays contribute to determinethe specific effects of damnacanthal on each of the steps of the angiogenic process, includinginhibition of tubulogenesis, endothelial cell proliferation, survival, migration and production ofextracellular matrix remodeling enzyme. Taken altogether, these results suggest thatdamancanthal could have potential interest for the treatment of cancer and other angiogenesisdependentdiseases.
PB Elsevier
YR 2017
FD 2017-01
LK http://hdl.handle.net/10630/14631
UL http://hdl.handle.net/10630/14631
LA eng
NO Cancer Letters 358 (2017) 1-11
NO Este es el manuscrito que fue aceptado y que finalmente se publicó en Cancer Letters con el DOI: 10.1016/j.canlet.2016.10.037
NO Supported by grants BIO2014-56092-R (MINECO and FEDER), P12-CTS-1507(Andalusian Government and FEDER) and funds from group BIO-267 (AndalusianGovernment). The "CIBER de Enfermedades Raras" is an initiative from the ISCIII(Spain). JAGV had the financial support of Vicerrectorado de Investigación yTransferencia (University of Málaga, Spain). The funders had no role in the studydesign, data collection and analysis, decision to publish or preparation of themanuscript.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 19 ene 2026