RT Journal Article
T1 Genetic architecture of nonadditive inheritance in Arabidopsis thaliana hybrids.
A1 Seymour, Danelle K
A1 Chae, Eunyoung
A1 Grimm, Dominik G.
A1 Martín-Pizarro, Carmen
A1 Habring- Müller, Anette
A1 Vasseur, François
A1 Rakitsch, Barbara
A1 Borgwardt, Karsten M.
A1 Koenig, Daniel
A1 Weigel, Detlef
K1 Arabidopsis thaliana
K1 Genética vegetal
K1 Factores de transcripción
AB The ubiquity of nonparental hybrid phenotypes, such as hybrid vigor and hybrid inferiority, has interested biologists for over acentury and is of considerable agricultural importance. Although examples of both phenomena have been subject to intense investigation, no general model for the molecular basis of nonadditive genetic variance has emerged, and prediction of hybrid phenotypes from parental information continues to be a challenge. Here we explore the genetics of hybrid phenotype in 435 Arabidopsis thaliana individuals derived from intercrosses of 30 parents in a half diallel mating scheme. We find that nonadditive genetic effects are a major component of genetic variation in this population and that the genetic basis of hybrid phenotype can be mapped using genome-wide association (GWA) techniques. Significant loci together can explain as much as 20% of phenotypic variation in the surveyed population and include examples that have both classical dominant and overdominant effects. One candidate region inherited dominantly in the half diallel contains the gene for the MADS-box transcription factor AGAMOUS-LIKE 50 (AGL50), which we show directly to alter flowering time in the predicted manner. Our study not only illustrates the promise of GWA approaches to dissect the genetic architecture underpinning hybrid performance but also demonstrates the contribution of classical dominance to genetic variance.
PB PNAS
YR 2016
FD 2016-11-01
LK https://hdl.handle.net/10630/36985
UL https://hdl.handle.net/10630/36985
LA eng
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026