RT Journal Article
T1 Advances and highlights in T and B cell responses to drug antigens
A1 Fernández-Santamaría, Rubén
A1 Ariza Veguillas, Adriana
A1 Fernández-Duarte, Tahía Diana
A1 Céspedes Lagos, José Antonio
A1 Labella, Marina
A1 Mayorga Mayorga, Cristobalina
A1 Torres-Jaén, María Josefa
K1 Inmunología
AB The immunological mechanisms involved in drug hypersensitivity reactions (DHRs) are complex, and despite important advances, multiple aspects remain poorly understood. These not fully known aspects are mainly related to the factors that drive towards either a tolerant or a hypersensitivity response and specifically regarding the role of B and T cells. In this review, we focus on recent findings on this knowledge area within the last 2 years. We highlight new evidences of covalent and non-covalent interactions of drug antigen with proteins, as well as the very first characterization of naturally processed flucloxacillin-haptenated human leukocyte antigen (HLA) ligands. Moreover, we have analysed new insights into the identification of risk factors associated with the development of DHRs, such as the role of oxidative metabolism of drugs in the activation of the immune system and the discovery of new associations between DHRs and HLA variants. Finally, evidence of IgG-mediated anaphylaxis in humans and the involvement of specific subpopulations of effector cells associated with different clinical entities are also topics explored in this review. All these recent findings are relevant for the underlying pathology mechanisms and advance the field towards a more precise diagnosis, management and treatment approach for DHRs.
PB Wiley
YR 2021
FD 2021-10-07
LK https://hdl.handle.net/10630/24060
UL https://hdl.handle.net/10630/24060
LA eng
NO Fernandez-Santamaria R, Ariza A, Fernandez TD, et al. Advances and highlights in T and B cell responses to drug antigens. Allergy.  2022;77:1129– 1138. https://doi.org/10.1111/all.15126
NO Funding for open access charge: Universidad de Málaga / CBUA.  This work has been supported by Institute of Health ‘Carlos III’ (ISCIII) of the Ministry of Economy and Competitiveness (MINECO) (grants co-funded by European Regional Development Fund: PI15/01206, PI17/01237, PI18/00095, RETICS ARADYAL RD16/0006/0001). Andalusian Regional Ministry of Health (grants PI-0241-2016, PE-0172-2018, PI-0127-2020). AA holds a Senior Postdoctoral Contract (RH-0099-2020) from Andalusian Regional Ministry of Health (cofunded by European Social Fund (ESF): ‘Andalucía se mueve con Europa’). ML holds a ‘Rio Hortega’ contract (CM20/00210) by ISCIII of MINECO (cofunded by ESF). CM holds a ‘Nicolas Monardes’ research contract by Andalusian Regional Ministry Health (RC-0004-2021).
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026