RT Journal Article
T1 Peripheral perfusion and oxygenation in areas of risk of skin integrity impairment exposed to pressure patterns. A phase I trial (POTER Study)
A1 García-Mayor, Silvia
A1 Morilla-Herrera, Juan Carlos
A1 Lupiáñez-Pérez, Inmaculada
A1 Kaknani-Uttumchandani, Shakira
A1 León-Campos, Álvaro
A1 Aranda-Gallardo, Marta
A1 Moya-Suárez, Ana Belén
A1 Morales-Asencio, José Miguel
K1 Úlceras por presión
AB Aim: The aim of this study was to analyse the change in peripheral oxygenationand microvascular flow in tissues subjected to different pressure regimes in healthysubjects and in hospitalized patients.Background: The presence of pressure ulcers in hospitalized patients is a commoncomplication that has a negative impact on health and often prolongs hospital stayand increases healthcare costs.Design: Experimental non-controlled, non-randomized study in two phases: pre-clinicaland clinical.Methods: The pre-clinical phase will be conducted in healthy volunteers and the clinicalphase, in patients at risk of impaired skin integrity. Vascular flow, tissue oxygenationand local temperature in areas at risk of pressure ulcers will be evaluated byDoppler laser in subjects lying on a capacitive surface to measure pressure at 10,249points. Different levels of pressure will be generated by changes in body position andchanges in tissue perfusion and oxygenation will be monitored for up to 4 hours, todetermine the implications for repositioning interventions in patients at risk. Thisstudy was funded in July 2015. The protocol is registered in ClinicalTrials.gov (NCT02736838).Discussion: Pressure ulcer is a significant and complex health problem in long-termbedridden patients and there is currently no effective treatment or efficient preventionmethod. The information provided by our study will provide an accurate assessmentof different thresholds for the onset of damage to the skin, associated withdifferent body positions and pressure levels.Trial Registration: The protocol is registered in ClinicalTrials.gov (NCT02736838).
PB Wiley
YR 2017
FD 2017-07-17
LK https://hdl.handle.net/10630/33931
UL https://hdl.handle.net/10630/33931
LA eng
NO García-Mayor S, Morilla-Herrera JC, Lupiáñez-Pérez I, Kaknani Uttumchandani S, León Campos Á, Aranda-Gallardo M, Moya-Suárez AB, Morales-Asencio JM. Peripheral perfusion and oxygenation in areas of risk of skin integrity impairment exposed to pressure patterns. A phase I trial (POTER Study). J Adv Nurs. 2018 Feb;74(2):465-471. doi: 10.1111/jan.13414. Epub 2017 Sep 15. PMID: 28792613
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 21 ene 2026