RT Conference Proceedings
T1 IPSC differentiation into ependymal progenitors to treat ventricular damage during hydrocephalus
A1 Rodríguez-Pérez, Luis Manuel
A1 Jiménez-Lara, Antonio Jesús
A1 Páez-González, Patricia
K1 Hidrocefalia
AB Introduction: During both obstructive congenital hydrocephalus and post-hemorrhagic hydrocephalus additional pathological events are intimately associated with their ethiology: a) a detrimental inflammatory response; b) severe damage of the underlying periventricular nervous tissue, including white matter, and c). Therapeutic approaches have been directed to overcome a) and b), however recovery of damaged neuroepithelium/ependyma is, in our present, an important therapeutic gap.Methods: Human and mouse induced pluripotent stem cells (iPSC) have been artificially differented into ependymal progenitors. Intracerebroventricular (ICV) injections of iPCS are performed ex vivo and in vivo in the damaged ventricular wall. Their integration and differentiation has been studied by immunohistochemistry and histopathological analysis.Results: Mice and human ependymal progenitors are able to integrate and differentiate into ependyma in damaged ventricular wall. Stage of ependymal differentiation by the time of the injection defined different degrees of integration. Conclusions: IPSC appear to be a good ependymal progenitor source with no ethical controversy associated.
YR 2018
FD 2018-10-30
LK https://hdl.handle.net/10630/16767
UL https://hdl.handle.net/10630/16767
LA eng
NO RyC 2014-16980Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 19 ene 2026