RT Journal Article
T1 Peripheral membrane proteins modulate stress tolerance by safeguarding cellulose synthases
A1 Kesten, Christopher
A1 García-Moreno, Álvaro
A1 Amorim-Silva, Vitor
A1 Menna, Alexandra
A1 Castillo-Garriga, Araceli
A1 Percio, Francisco
A1 Armengot, Laia
A1 Ruiz-López, Noemí
A1 Jaillais, Yvon
A1 Sánchez-Rodríguez, Clara
A1 Botella-Mesa, Miguel Ángel
K1 Celulosa-Síntesis
AB Controlled primary cell wall remodeling allows plant growth under stressful conditions, but how these changes are conveyed to adjust cellulose synthesis is not understood. Here, we identify the TETRATRICOPEPTIDE THIOREDOXIN-LIKE (TTL) proteins as new members of the cellulose synthase complex (CSC) and describe their unique and hitherto unknown dynamic association with the CSC under cellulose-deficient conditions. We find that TTLs are essential for maintaining cellulose synthesis under high-salinity conditions, establishing a stress-resilient cortical microtubule array, and stabilizing CSCs at the plasma membrane. To fulfill these functions, TTLs interact with CELLULOSE SYNTHASE 1 (CESA1) and engage with cortical microtubules to promote their polymerization. We propose that TTLs function as bridges connecting stress perception with dynamic regulation of cellulose biosynthesis at the plasma membrane.
PB American Association for the Advancement of Science
YR 2022
FD 2022-11-16
LK https://hdl.handle.net/10630/34503
UL https://hdl.handle.net/10630/34503
LA eng
NO Christopher Kesten et al. ,Peripheral membrane proteins modulate stress tolerance by safeguarding cellulose synthases.Sci. Adv.8,eabq6971(2022).DOI:10.1126/sciadv.abq6971
NO This work was funded by the Spanish Ministry for Science and Innovation (MCIN/AEI/ 10.13039/501100011033 1-PID2020-114419RB-I00, PGC2018-098789-B-I00, and PID2019-107657RB-C22 to M.A.B., N.R.-L., and A.G.C., respectively), the Andalusian Research Plan cofinanced by the European Union (PAIDI 2020-PY20_00084 and UMA20-FEDERJA-023) to M.A.B. and Junta de Andalucía UMA-FEDER project (UMA18-FEDERJA-154) to N.R.-L., and the Swiss National foundation to C.S.-R. (SNF 31003A_163065/1 to AM). C.K. was supported by a Peter und Traudl Engelhorn-Stiftung fellowship, an ETH Career Seed Grant (SEED-05 19-2) of the ETH Foundation, an Emerging Investigator grant (NNF20OC0060564) of the Novo Nordisk Foundation, and an Experiment grant (R346-2020-1546) of the Lundbeck foundation. Á.G.-M. was supported by BES-2015-071256 and EMBO Short-Term 7632 Fellowships. F.P. was supported by and FPU19/02219 fellowship. V.A.-S. was supported by an Emerging Investigator research project (UMA20-FEDERJA-007) and cofinanced by the “Programa Operativo FEDER 2014-2020” and by the “Consejería de Economía y Conocimiento de la Junta de Andalucía”. Y.J. was funded by the Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (grant agreement no. 101001097).
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 19 ene 2026