RT Journal Article T1 Turning around Cycles: An Approach Based on Selected Problems/Cases to Stimulate Collaborative Learning about Krebs and His Four Metabolic Cycles A1 Medina-Torres, Miguel Ángel A1 García-Ponce, Ángel Luis A1 Blanco-López, Ángel A1 Rodríguez-Quesada, Ana María A1 Urdiales-Ruiz, José Luis A1 Fajardo-Paredes, Ignacio José A1 Suárez-Marín, María Fernanda A1 Alonso-Carrión, Francisco José K1 Metabolismo AB Metabolism is a challenging subject for bioscience students due to the intrinsic complexity of the metabolic network, as well as that of the overlapping mechanisms of metabolic regulation. Collaborative learning based on a problem-based learning approach can help students to successfully learn and understand metabolism. In the present article, we propose a selection of exercises, problems, and cases aimed to focus students’ attention on the scientific work made by Sir Hans Krebs and his collaborators to elucidate four main metabolic cycles, as well as on the study of these cycles, their regulation, and their metabolic integration. The objectives, the tools, and the implementation of this proposal are described, and the results obtained during its first implementation with volunteer students enrolled in two courses on metabolic regulation at our university are presented and discussed. These volunteer students signed a learning contract and were randomly distributed in small groups (3–4 students each). Application of this collaborative learning activity to our classrooms has been very satisfactory, as evidenced by an improvement in the volunteers’ academic performance and a very positive perception by most of them, who declared to be “very satisfied” or “satisfied” with their experience and felt that they had learned more. PB ACS YR 2022 FD 2022-05-25 LK https://hdl.handle.net/10630/24535 UL https://hdl.handle.net/10630/24535 LA eng NO Medina, Miguel Ángel : García-Ponce, Ángel Luis ; Blanco-Lopez, Angel ; Quesada, Ana R. ; Urdiales-Ruiz, Jose Luis ; Fajardo-Paredes, Ignacio José ; Suarez-Marin, Maria Fernanda ; Alonso-Carrion, Francisco Jose ; J. Chem. Educ. 2022, 99, 6, 2270–2276. https://doi.org/10.1021/acs.jchemed.1c01038 NO This work was supported by the University of Málaga (Spain) with funds granted to the educational innovation projects PIE15-163, PIE17-145, and PIE19-057. The experimental work carried out by our group is supported by grants PID2019-105010RB-I00 and EDU2017-82197-P (Spanish Ministry of Science and Innovation), UMA18-FEDERJA-220 (Andalusian Government and FEDER), as well as PY20_00257 and funds from PAIDI group BIO 267 (Andalusian Government). Funding for open access charge: Universidad de Málaga / CBUA DS RIUMA. Repositorio Institucional de la Universidad de Málaga RD 19 ene 2026