RT Conference Proceedings
T1 Synthesis of New Analogues of the Bengamides to encapsulate in magnetic nanoparticles.
A1 Ortega Rodríguez, Alicia
A1 Porras Alcalá, Cristina
A1 Contreras-Cáceres, Rafael
A1 López-Romero, Juan Manuel
A1 Melguizo, Consolación
A1 Prados, José Carlos
K1 Nanoparticulas magneticas
K1 Esponjas marinas - Microbiología
AB The development and identification of new antitumoral has become a research area of great interest and maximum priority due to secondary effects of current antitumoral and the appearance of tumours resistant to these agents. Marine sponges corresponding to the Jaspidae family have proved to be a prolific source of bioactive natural products. Among these, the Bengamides have showed an important biological profile, including antitumor, antibiotic and anthelmintic properties. Due to the interest of theses natural products, we describe a study directed towards the total synthesis of this class of compounds. Then we encapsulate Bengamides in temperature sensitive microgels with a magnetic core. Magnetic nanoparticles (Fe3O 4) were prepared by coprecipitation method and the surface was functionalized by acrylic acid. Polymer poly(N-isopropylacrylamide) (PNIPAM) were grown by free radical polymerization in presence of cross-liker and initiator.
YR 2019
FD 2019-05-15
LK https://hdl.handle.net/10630/17659
UL https://hdl.handle.net/10630/17659
LA eng
NO Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 21 ene 2026