RT Journal Article
T1 Generation of a humanized Aβ expressing mouse demonstrating aspects of Alzheimer's disease-like pathology.
A1 Baglietto-Vargas, David
A1 Forner, Stefania
A1 Cai, Lena
A1 Martini, Alessandra C
A1 Trujillo-Estrada, Laura
A1 Swarup, Vivek
A1 Minh Thu Nguyen, Marie
A1 Do Huynh, Kelly
A1 Javonillo, Dominic I
A1 Minh Tran, Kristine
A1 Phan, Jimmy
A1 Jiang, Shan
A1 Kramár, Enikö A
A1 Nuñez-Diaz, Cristina
A1 Balderrama-Gutierrez, Gabriela
A1 Garcia, Franklin
A1 Childs, Jessica
A1 Rodriguez-Ortiz, Carlos J
A1 Garcia-Leon, Juan Antonio
A1 Kitazawa, Masashi
A1 Shahnawaz, Mohammad
A1 Matheos, Dina P
A1 Ma, Xinyi
A1 Da Cunha, Celia
A1 Walls, Ken C
A1 Ager, Rahasson R
A1 Soto, Claudio
A1 Gutierrez, Antonia
A1 Moreno-Gonzalez, Ines
A1 Mortazavi, Ali
A1 Tenner, Andrea J
A1 MacGregor, Grant R
A1 Wood, Marcelo
A1 Green, Kim N
A1 LaFerla, Frank M
K1 Alzheimer, Enfermedad de
AB The majority of Alzheimer’s disease (AD) cases are late-onset and occur sporadically, however most mouse models of the disease harbor pathogenic mutations, rendering them better representations of familial autosomal-dominant forms of the disease. Here, we generated knock-in mice that express wildtype human Aβ under control of the mouse App locus. Remarkably, changing 3 amino acids in the mouse Aβ sequence to its wild-type human counterpart leads to age-dependent impairments in cognition and synaptic plasticity, brain volumetric changes, inflammatory alterations, the appearance of Periodic Acid-Schiff (PAS) granules and changes in gene expression. In addition, when exon 14 encoding the Aβ sequence was flanked by loxP sites we show that Cre-mediated excision of exon 14 ablates hAβ expression, rescues cognition and reduces the formation of PAS granules.
PB Springer Nature
YR 2021
FD 2021-04-23
LK https://hdl.handle.net/10630/33784
UL https://hdl.handle.net/10630/33784
LA eng
NO Baglietto-Vargas, D., Forner, S., Cai, L. et al. Generation of a humanized Aβ expressing mouse demonstrating aspects of Alzheimer’s disease-like pathology. Nat Commun 12, 2421 (2021). https://doi.org/10.1038/s41467-021-22624-z
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 4 mar 2026