RT Journal Article
T1 An olefin metathesis approach towards the solomonamides.
A1 Cheng-Sánchez, Iván
A1 García-Ruiz, Cristina
A1 Sarabia-García, Francisco Ramón
K1 Química clínica
AB A new synthetic strategy directed towards the solomonamides, a novel class of cyclopeptides of marine origin, has been developed utilizing an olefin metathesis reaction to form the [15]-membered ring contained in these natural products. We demonstrated the efficiency and validity of this synthetic approach for the construction of the macrocyclic core of the solomonamides in a minimally oxidized system. In fact, the olefin metathesis cyclization proceeded in a stereoselective manner to provide exclusively the Z-isomer in high yield. The described synthetic strategy for the solomonamides allows for access to the natural products, as well as offering the opportunity for the generation of a diverse set of analogues in the subsequent oxidation phase
PB Elsevier
YR 2016
FD 2016
LK https://hdl.handle.net/10630/34739
UL https://hdl.handle.net/10630/34739
LA eng
NO Cheng-Sánchez, I.; García-Ruiz, C.; Sarabia, F. An olefin metathesis approach towards the solomonamides. Tetrahedron Lett. 2016, 57, 30, 3392-3395 https://doi.org/10.1016/j.tetlet.2016.06.081
NO Política de acceso abierto tomada de: https://v2.sherpa.ac.uk/id/publication/15870
NO This work was financially supported by the Ministerio de Economía y Competitividad (MINECO) (CTQ2014-60223-R). I.C.-S. thanks the Ministerio de Educación, Cultura y Deporte for a predoctoral fellowship (FPU Programme). C.G.-R. thanks Ministerio de Educación y Ciencia and Research Plan of the University of Málaga for predoctoral and postdoctoral fellowships, respectively. The authors thank Dr. J.I. Trujillo from Pfizer (Groton, CT) for assistance in the preparation of this manuscript. The authors thank the Unidad de Espectroscopía de Masas and the NMR facility of the University of Málaga for exact mass and NMR spectroscopic assistance.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 21 ene 2026